Gastroenterology Clinical Studies

Some of the many research opportunities available in Gastroenterology are listed below. Select a study to review a brief description and requirements. Parents or guardians of children who might be eligible are encouraged to inquire about enrollment. Contact information is listed at the end of each study.

Thank you for exploring these opportunities and helping us to find cures and prevent childhood disease.

Clinical Studies

Researchers

Biliary Atresia Long-Term Observation: The BASIC Study

Biliary Atresia Study in Infants, Children and Adults

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Biliary Atresia Treatment with Maralixibat after Kasai Procedure: The EMBARK Study – Phase II

Study to Evaluate Maralixibat in the Treatment of Subjects with Biliary Atresia after Hepatoportoenterostomy

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Cholestasis Long-term Observation: The LOGIC Study

Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)

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Cholestasis Natural History Database: The PROBE Study

A Prospective Database of Infants with Cholestasis

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Cholestatic Liver Disease Treatment with Maralixibat: The RISE Study – Phase II

Study to Evaluate Maralixibat in the Treatment of Infants with Cholestatic Liver Diseases Including Progressive Familial Intrahepatic Cholestasis and Alagille Syndrome

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Crohn’s Disease Maintenance Therapy with Vedolizumab – Phase III

Study to Evaluate Vedolizumab Intravenous as Maintenance Therapy in Pediatric Subjects with Moderately to Severely Active Crohn’s Disease Who Achieved Clinical Response Following Open-Label Vedolizumab Intravenous Therapy

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Erosive Esophagitis Healing Maintenance Therapy with Protonix – Phase II

Study of Oral Pantoprazole in Pediatric Participants who Require Maintenance Therapy for Healed Erosive Esophagitis

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IBD ImproveCareNow Registry

Using Patient Data to Transform Care and Improve Outcomes for Children, Adolescents and Young Adults with Inflammatory Bowel Disease

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Liver Disease Scarring: The FORCE Study

FibroScan® in Pediatric Cholestatic Liver Disease Study

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Mitochondrial Hepatopathies Long-term Observation: The MITOHEP Study

Longitudinal Study of Mitochondrial Hepatopathies

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Nonalcoholic Fatty Liver/Steatohepatitis (NAFL/NASH) Observational Study

A 5-year Longitudinal Observational Study of Patients with Nonalcoholic Fatty Liver or Nonalcoholic Steatohepatitis

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Pancreatitis INSPPIRE 2 Study

Pediatric Longitudinal Cohort Study of Chronic Pancreatitis (INSPPIRE 2)

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Primary Sclerosing Cholangitis Observational Study

Prospective Observational Study of Primary Sclerosing Cholangitis in Children, a Protocol of the Childhood Liver Disease Research Network

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Ulcerative Colitis Maintenance Therapy with Vedolizumab – Phase III

Study to Evaluate Vedolizumab Intravenous as Maintenance Therapy in Pediatric Subjects with Moderately to Severely Active Ulcerative Colitis Who Achieved Clinical Response Following Open–Label Vedolizumab Intravenous Therapy

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*Original research initiated by investigators at UPMC Children’s Hospital of Pittsburgh.