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The National Institutes of Health-funded D3VH research study will help researchers understand whether increasing the vitamin D levels of vitamin D-deficient children with obesity can improve their heart-health. Obese and overweight children have a higher chance of having cardiovascular disease risk factors and vitamin D deficiency, which itself is a cardiovascular risk factor. Childhood heart-health risk factors can track into adulthood. Potentially, improvement of cardiovascular health of obese and overweight children through vitamin D supplementation may reduce their risk of heart disease later in life.
Subject to certain exclusion criteria, the D3VH study is enrolling healthy 10- to 18-year-old obese and overweight children (body mass index in 85th percentile or higher), who are found to be vitamin D-deficient in the screening evaluation.
Boys and Girls: Ages 10 to 18
Eligible participants will have 3 study visits over 6 months at the Clinical and Translational Research Center at the Montefiore Hospital of UPMC in Oakland. Enrolled children will be randomly assigned to take one of 3 dose levels of vitamin D3 in tablet form (600 IU or 1000 IU or 2000 IU) once a day for 6 months. Study procedures will include vascular function testing, body composition assessment, blood tests, and questionnaires.
Duration: 6 months
National Heart, Lung, and Blood Institute (NHLBI)
Study Description at National Institutes of Health
Kumaravel Rajakumar, MD, MS
For more information about the study or enrollment, please contact:
or Study Coordinator Flora Olabopo, BS
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.