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This multi-center study examines whether antibodies affect the outcomes of pediatric heart transplants. Antibodies are proteins in the blood that the body makes to fight off infections. Although white blood cells are known to play a significant role in organ rejection, researchers theorize that a child’s body might also use antibodies against a newly transplanted heart. This study will measure antibodies in the blood, and researchers will perform tests to see how they might affect the heart. Another goal is to develop a blood test to help predict when antibodies are damaging the heart. Children’s Hospital of Pittsburgh of UPMC is one of the seven hospitals in the Clinical Trials in Organ Transplantation in Children (CTOT-C) consortium pursing this research.
Subject to certain exclusions, this study is only open to prospective pediatric heart transplant patients.
Males: Up to age 21
Females: Up to age 21
Blood draws will be taken at various intervals, starting from prior to transplant through three years after the transplant. Researchers will be testing blood samples for antibodies that may react with the donor heart.
Visits: None beyond normal care for heart transplant
Duration: 3 years
National Institute of Allergy and Infectious Diseases
National Heart, Lung and Blood Institute
Study Description at National Institutes of Health
Brian Feingold, MD
For information, please contact:
Jane Luce, MHP, CHES
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.