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Children's Hospital is ranked One of America's Best Children's Hospitals.
The purpose of this research study, initiated at Children’s Hospital of Pittsburgh of UPMC, is to assess the effectiveness of the GAA/TT-peptide vaccine, made from small proteins called peptides and Montanide ISA-51, when used against low-grade gliomas that have grown back despite radiation and/or chemotherapy. The vaccine is intended to use the child’s immune system to attack the abnormal brain tumor cells in much the same way as conventional vaccines prepare the immune system to respond to specific microbes that may attack in the future.
Subject to certain exclusion criteria, this study is open to pediatric patients of both genders, ages 12 months to 21 years, who have low-grade gliomas that have grown back after treatment with radiation and/or chemotherapy.
Males and Females: Ages 12 months to 21 years
Following screening for eligibility, participants will receive injections of the vaccine and Poly-ICLC, a drug that helps the immune system respond to the vaccine. These will be given every three weeks for 21 weeks, for an initial total of 8 injections. Barring negative side effects or tumor worsening, the injections may continue at a rate of every 6 weeks for up to 2 years from the first vaccine injection (14 additional injections).
Visits: From 9 to 23, depending on response to therapy
Duration: Up to 2 years
Children’s Hospital of Pittsburgh of UPMC, Brain Tumor Translational Research Fund University of Pittsburgh
Study Description at National Institutes of Health
Jean Tersak, MD
For more information about the study or enrollment, please contact:
Research Coordinator Angela Connelly, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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