Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Ranked #8 Nationally by U.S. News & World Report.
This Children’s Oncology Group clinical trial is studying effects of temozolomide and irinotecan together, provided with or without bevacizumab, in treating young patients with recurrent or refractory medulloblastoma or central nervous system (CNS) primitive neuroectodermal tumors (PNET). The combination of temozolomide and irinotecan has been used to treat adults and children with other types of cancer. Researchers believe this combination may help in treating medulloblastoma and PNET, and would like to determine if adding bevacizumab improves outcomes.
Subject to certain exclusion criteria, this study is open to children and young adults, up to 21 years of age, who have a medulloblastoma or PNET that has relapsed or become refractory to standard chemotherapy.
Males and Females: Up to 21 years old
Participants will be randomly assigned to either a group that receives temozolomide and irinotecan or one that receives this drug combination along with bevacizumab. Treatment cycles last 4 weeks and require 5 consecutive days of drug therapy followed by 23 without. After 2 cycles, participants’ tumors will be evaluated, with a determination made as to whether to remain for more cycles – potentially up to 12.
Visits: Requires monthly visits each cycle for patients receiving temozolomide irinotecan; Twice-monthly visits for patients receiving bevacizumab
Duration: Up to 48 weeks
Children’s Oncology Group (Study ACNS0821)
National Cancer Institute
Study Description at National Institutes of Health
Jean Tersak, MD
For more information about the study or enrollment, please contact:
Research Coordinator Angela Krol, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.