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This Children’s Oncology Group clinical trial is studying effects of temozolomide and irinotecan together, provided with or without bevacizumab, in treating young patients with recurrent or refractory medulloblastoma or central nervous system (CNS) primitive neuroectodermal tumors (PNET). The combination of temozolomide and irinotecan has been used to treat adults and children with other types of cancer. Researchers believe this combination may help in treating medulloblastoma and PNET, and would like to determine if adding bevacizumab improves outcomes.
Subject to certain exclusion criteria, this study is open to children and young adults, up to 21 years of age, who have a medulloblastoma or PNET that has relapsed or become refractory to standard chemotherapy.
Males and Females: Up to 21 years old
Participants will be randomly assigned to either a group that receives temozolomide and irinotecan or one that receives this drug combination along with bevacizumab. Treatment cycles last 4 weeks and require 5 consecutive days of drug therapy followed by 23 without. After 2 cycles, participants’ tumors will be evaluated, with a determination made as to whether to remain for more cycles – potentially up to 12.
Visits: Requires monthly visits each cycle for patients receiving temozolomide irinotecan; Twice-monthly visits for patients receiving bevacizumab
Duration: Up to 48 weeks
Children’s Oncology Group (Study ACNS0821)
National Cancer Institute
Study Description at National Institutes of Health
Jean Tersak, MD
For more information about the study or enrollment, please contact:
Research Coordinator Angela Krol, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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