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The goal of this multicenter trial by the Children’s Oncology Group is to determine the effects and efficacy of AZD1775 (MK-1775) in combination with irinotecan for treatment of relapsed or refractory solid tumors. Adult cancer studies have demonstrated that MK-1775 be safely added to standard chemotherapy regimens to with the goal of increasing effectiveness, This study combines MK-1775 with irinotecan, which is an active chemotherapy agent against a variety of pediatric cancers.
Subject to certain exclusion criteria, this study is open to patients of both genders ages 1 to 21, who have been diagnosed as having relapsed or refractory solid tumors, neuroblastoma, medulloblastoma or central nervous system primitive neuroectodermal tumor (PNET).
Males and Females: Ages 1 to 21
Patients enrolled in the study will be given oral doses of MK-1775 along with irinotecan for the first 5 days of a 21-day cycle. Patients may continue to receive the study drugs for up to 18 cycles, unless serious side effects occur or the tumor worsens.
Visits: 4 for the first month, with weekly labwork, then monthly with weekly labwork in patients who remain on study
Duration: Up to 54 weeks, depending on outcomes
Children’s Oncology Group (ADVL1312)
National Cancer Institute
Study Description at National Institutes of Health
Jean Tersak, MD
For more information about the study or enrollment, please contact:
Research Coordinator Angela Connelly, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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