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This Children’s Oncology Group Phase I trial studies the effects of crizotinib given together with conventional chemotherapy in treating younger patients with relapsed or refractory solid tumors or anaplastic large cell lymphoma (ALCL). Crizotinib may stop tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
Subject to certain exclusion criteria, this study is open to males and females, ages 1 to 21 years with relapsed or refractory solid tumors or ALCL, excluding central nervous system tumors.
Males and Females: Ages 1 to 21 years
Study participants will be placed in one of two study arms. Participants will receive 2 oral doses of crizotinib each day for a 21-day cycle. Those enrolled in Part A of the study will also receive a venous infusion of topotecan and cyclophosphamide on days 1-5 of each cycle. Those in Part B will receive an infusion of vincristine, doxorubicin and dexrazoxane each treatment day. Participation may continue for up to 24 months, or 35 cycles of therapy.
Visits: Weekly during first cycle, then monthly in subsequent cycles, with periodic lab evaluations and scans
Duration: Up to 2 years if tumor is responding and patient has no dose-limiting side effects
Children’s Oncology Group (Study ADVL1212)
National Cancer Institute
Study Description at National Institutes of Health
Jean Tersak, MD
For more information about the study or enrollment, please contact:
Research Coordinator Angela Krol, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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