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The purpose of this multi-site study is to determine if certain types of tests and exams can help with early screening, diagnosis and treatment of brain injury in newborns as well as identify a connection between MR imaging (magnetic resonance imaging and magnetic resonance spectroscopy) and neuro-developmental outcome. Through this protocol, researchers will collect and compare information from cranial ultrasounds, MR imaging scans, neurological exams and neuropsychological assessments of children.
The study is open to newborn infants of both genders, who were born premature, have congenital heart disease or were born full-term and healthy.
With parental permission, researchers will conduct MR brain imaging and/or cranial ultrasound of participating newborns. Alternately, researchers will collect existing information in cases where clinical brain imaging or cranial ultrasound scans were already performed as part of a child’s standard care. When participants are about 18 months of age, a neuropsychologist will conduct developmental tests. At age 3, and again at age 6, participants will receive a short neurological exam followed by a visit with a neuropsychologist. Also at age 6, additional MR imaging will be performed.
Duration: 6 years
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Ashok Panigrahy, MD
For information or to enroll, please contact:
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UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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