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The goal of this multi-center TrialNet study is to learn if the drug CTLA-4 Ig, also known as abatacept, can help people with newly diagnosed type 1 diabetes by delaying or stopping further destruction of insulin-producing beta cells. Researchers will perform blood tests and will collect information about participants’ diabetes to learn how abatacept works when given to people with newly diagnosed type 1 diabetes.
The study includes candidates diagnosed with type 1 diabetes within 3 months of enrolling.
Males: Ages 6 to 45
Females: Ages 6 to 45
Participation involves a series of visits to Children’s Hospital of Pittsburgh of UPMC for blood testing and administration of the study drug or a placebo, as determined by random assignment. Three dosages will be given in the first month, followed by monthly dosages thereafter for a total of 27 infusions. Participants also commit to intensive diabetes management.
Duration: 2 years
American Diabetes Association
Juvenile Diabetes Research Foundation
National Institute of Allergy and Infectious Diseases
National Institute of Child Health and Human Development
National Institute of Diabetes and Digestive and Kidney Diseases
Study description at National Institutes of Health
Dorothy Becker, MBBCh
Karen Riley, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.