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The primary purpose of this 3-part TrialNet study is to learn more about how Type 1 diabetes (T1D) occurs and will be done via screening close blood relatives of people with T1D. The presence of diabetes-related autoantibodies will be determined through blood draws, which can signify the cells in the pancreas that produce insulin are damaged. A positive result will lead to participation in the additional phases. The second and third phases will be used to follow the participant throughout the study to see if there are changes or if the participant develops diabetes. Those at risk of T1D may qualify for other TrialNet studies to prevent diabetes. About 200,000 participants will be screened for this study, with participants coming from locations both internationally and from Children’s Hospital of Pittsburgh of UPMC.
Eligible participants encompass males and females age 1 to 45 years who have an immediate or extended blood relative with T1D, but have not themselves been diagnosed with diabetes.
Males: age 1 to 45
Females: age 1 to 45
Children will have a yearly blood sample until the age of 18. Adults will have a single blood sample. In addition about 5 percent of subjects will qualify for an oral glucose tolerance test in Phase 2 and Phase 3 to determine changes or if the participant has developed diabetes. Participants should plan on clinic visits once or once a year during the first phase of the study and every 6 months during phase 2 and 3.
Visits: Determined by age of participant
Duration: Open ended
National Institutes of Health
Juvenile Diabetes Research Foundation
American Diabetes Association
Study Description at National Institutes of Health
Type 1 Diabetes TrialNet
Dorothy J. Becker, MBBCh
To get started, please contact:
Karen RIley, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.