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The TrialNet Oral Insulin Diabetes Prevention Study seeks to determine whether repeated intervention with oral insulin prevents or delays the development of Type 1 Diabetes Mellitus (T1DM) in non-diabetic relatives of patients with T1DM. Eligible relatives for the study are those who have antibodies to the body’s own insulin and do not have any blood sugar abnormalities. Results from previous tests suggest that oral insulin may delay diabetes in people with higher levels of insulin autoantibodies. This new multi-center study seeks to determine if these findings are true in similar groups of people.
Eligible participants include children and adults, who do not have diabetes of any kind, have participated in the TrialNet Natural History study and have had tests that show they have normal glucose levels, but have certain markers associated with an increased risk of developing T1DM. Candidates should be age 3 to 45, and have a sibling or parent with T1DM; or age 3 to 20, and have a cousin, aunt, uncle, niece, nephew, half-sibling or grandparent with T1DM.
Males: age 3 to 45
Females: age 3 to 45
Following an initial screening visit, there will be a 3-month visit, and thereafter participants will have clinic visits every 6 months throughout the length of this study. At each visit, a physical, blood tests and other health measurements will be done.
Visits: Number of visits dependent on whether participant develops T1DM Type 1 diabetes and duration of the study
Duration: Ongoing through 2014
Study Description at National Institutes of Health
Type 1 Diabetes TrialNet
Dorothy J. Becker, MBBCh
To get started, please contact:
Karen Riley, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.