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This research study is being done to determine if rituximab can stop the loss of cells that make insulin in those who have recently developed Type 1 diabetes. Insulin is a hormone needed by the body to use glucose for energy and growth. Rituximab is approved for the treatment of a blood condition called lymphoma and for rheumatoid arthritis and potentially can assist the body in continuing to produce its own insulin.
The study is closed to enrollment but subjects enrolled elsewhere may transfer to the CHP site. Participants are between the ages of 8 and 45 years of age.
Males: age 8 to 45
Females: age 8 to 45
Follow up procedures involve clinical visits over 2 or possibly 4 years. After the first two years of the study, patients still making insulin will be asked to return every 6 months for another 2 years. A total of 87 people throughout all TrialNet sites are taking part in this study.
Duration: 2 to 4 years
National Institute of Health
National Institute of Diabetes, Digestive & Kidney Disease
Study Description at National Institutes of Health
Type 1 Diabetes TrialNet
Dorothy Becker, MBBCh
For information, please contact:
Karen Riley, RN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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