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The purpose of this study is to test the investigational drug liraglutide when used by adolescents with obesity. Liraglutide, which has been approved under the name Saxenda® for use in adults, is a modified form of GLP-1, a hormone produced naturally by the intestines that increases the feeling of fullness/satiety and leads to eating less food. Researchers believe it may also help adolescents to lose weight.
Subject to certain exclusion criteria, this study is enrolling participants of both genders, ages 12 through 17, who have a body weight that is higher than normal for their ages.
Males and Females: Ages 12 through 17
The study is divided into two parts. In the first 12 weeks, participants will attend up to 6 visits, where they will discuss healthy eating and physical activity. Adolescents who meet all study criteria will be enrolled in the second part of the study, an 82-week program in which the study medications or a placebo are taken for 56 weeks and counseling in healthy nutrition and physical activity continued for 26 more weeks. By randomization, participants will receive either liraglutide or the placebo, to be given by self-injection using a special pen. During this time, participants will have 22 visits to the study site for assessments, blood tests, other physical exams, and dose adjustments. Researchers will monitor for changes in body mass index along with other metabolic factors.
Visits: Up to 28
Duration: About 1 year, 10 months
Study Description at National Institutes of Health
Endocrinology, Diabetes and Metabolism Research
Center for Pediatric Research in Obesity and Metabolism
Silva Arslanian, MD
For more information about the study or enrollment, please contact:
Study Coordinator Nancy Guerra, CRNP
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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