Children's Hospital is part of the UPMC family.
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To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Children's Hospital is ranked One of America's Best Children's Hospitals.
Our long-term goal is to develop a novel vaccination strategy against opportunistic infections in HIV/AIDS patient as well as immunocompromised persons. We have identified a novel vaccine candidate for Pneumocystis termed mini-kexin. We are investigating how host CD4+ T lymphocytes participate in systemic and mucosal immune responses to the kexin vaccine.
Airway epithelial cells are the initial point of contact for lung pathogens. In response to inflammatory stimuli, they produce anti-microbial peptides, reactive oxygen species, chemokines, anti-apoptotic and proliferative genes. We are studying the roles of T cells, IL-17 and IL-22 in these processes. It is our goal to discover novel gene expression patterns in epithelial cells that are caused by infections, inflammation and injury, and to test new therapeutic targets.
We study the relationship between airway epithelial cells, dendritic cells and T cells during the initiation of inflammation and resolution of infection. Click for larger image.
We are working to better understand the role of host defense against Pneumocystis, particularly the role of anti-fungal carbohydrate antibodies. The cell walls of most fungal species, including Pneumocystis, contain the two carbohydrate polymers beta-1,3-glucan and chitin, and our lab has shown that antibodies against these carbohydrate antigens are a component of the natural antibody repertoire of multiple species. These IgM antibodies participate in early clearance of Pneumocystis organisms from the lung and influence the generation of the adaptive immune response.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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