Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Children's Hospital is ranked One of America's Best Children's Hospitals.
We are interested in vitamin D mediated immune tolerance. Aspergillus fumigatus (Af) is the most prevalent fungal organism that colonizes in the respiratory tract of cystic fibrosis (CF) patients.
Though colonization rates are high in CF patient populations, only 4 to 15 percent develop clinical disease in response to Af, allergic bronchopulmonary aspergillosis (ABPA).
ABPA is characterized by a dominant Th2 response to Af. Further, we have shown that patients with ABPA are significantly more vitamin D deficient than CF patients without ABPA indicating that vitamin D deficiency may be a causal factor in the development of ABPA.
We have started a clinical trial to determine if vitamin D supplementation will reduce total and aspergillus-specific IgE levels in CF patients with ABPA. In addition, we have established a mouse model of vitamin D deficiency in order to determine how vitamin D mediates disease tolerance versus sensitization.
Vitamin D acting on APC-T cell interactions, inhibiting Th17 and Th2 proliferation while increasing Treg frequency.Click to view larger image.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to: