Children's Hospital is part of the UPMC family.
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To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
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For more information about research, please call our main office at 412-692-6438.
Children's Hospital is ranked One of America's Best Children's Hospitals.
The major research goal of Principal Investigator Jay Kolls, MD, is to investigate mechanisms of lung host defenses in normal and immunocompromised hosts. Presently, he is investigating how IL-23 and IL-17 regulate neutrophil recruitment in response to infectious stimuli in the lung. To this end, he studies cellular sources of IL-17A, IL-17F, and IL-22 in the lung and liver as well as their signaling in response to pulmonary infection or hepatitis.
Dr. Kolls also has long-standing interests in determining if Th17 cells and their cytokine products contribute to airway destruction in cystic fibrosis, and in understanding cytokine biology in the lung through over-expression or dominant negative inhibitor strategies using somatic gene transfer. In these studies, he has identified that sub-populations of CD8+ T cells polarized in vivo via cytokine gene transfer have effector activity against P. carinii.
Dr. Kolls is presently using gene expression profiling and proteomics to define this effector activity. He also has a program in developing a CD4-independent vaccination against AIDS-related opportunistic infections.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to: