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An attending neonatologist and an assistant professor/early-stage investigator in Pediatrics, Developmental Biology and Immunology at the University of Pittsburgh School of Medicine, Liza Konnikova’s focus is on the development of neonatal immunity at mucosal surfaces and its role in the pathogenesis of diverse diseases such as sepsis, preterm labor, necrotizing enterocolitis and very-early onset IBD (VEO-IBD). Her postdoctoral training focused on the development of gastrointestinal (GI) tolerance in children. Through collaborative initiatives, she has shown that a novel subtype of regulatory T-cells exists in the human GI tract and is important in controlling Th17.
In Dr. Konnikova’s studies of the role of IL10 signaling in mucosal immune development, she has demonstrated that IL10R-deficient patients develop a profound increase in pro-inflammatory cytokines such as IL1b and IL17.
She has pioneered the application of mass cytometry to frozen mucosal biopsies, helping to improve our understanding of mucosal immunity. This innovation has helped to identify novel populations of immune cells in VEO-IBD and to perform serial monitoring of IBD activity in drug trials. In addition to continuing studies on GI immune development in infants and young children, her lab is applying these techniques to gain a better understanding of placental immune development and postulates that there are potential infection-independent immune triggers in the placenta that induce preterm labor and set up a pro-inflammatory cascade in the infants.
Board-certified in Pediatrics and Neonatal-Perinatal Medicine, Dr. Konnikova, sees patients through the division of Newborn Medicine at UPMC Children’s Hospital of Pittsburgh. For appointments call 412-692-5030.
View Dr. Konnikova’s full list of publications on PubMed.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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