Doctor

Assistant Professor, University of Pittsburgh School of Medicine
Assistant Professor, Department of Developmental Biology, University of Pittsburgh School of Medicine

Services

Stars No Patient
Satisfaction Reviews
Why not?
SHOW ALL RATINGS+
Specialty:

Pediatrics

Secondary Specialty:

Neonatal-Perinatal Medicine

Board Certifications:

Neonatal - Perinatal Medicine
Pediatrics

Education:

MD, Tufts University School of Medicine Boston, MA

Residency:

Boston Children's Hospital
Boston, MA

Fellowships:

Boston Children's Hospital
Boston, MA

Affiliations:

UPMC Magee-Womens Hospital
UPMC Horizon
UPMC Mercy
UPMC Altoona
UPMC Children's Hospital of Pittsburgh
UPMC Williamsport

Languages:

Russian

Liza Konnikova, MD, PhD, FAAP

Doctor

Assistant Professor, University of Pittsburgh School of Medicine
Assistant Professor, Department of Developmental Biology, University of Pittsburgh School of Medicine

Services

Locations and Directions

SHOW ALL LOCATIONS+

Biography

Research Interests

An attending neonatologist and an assistant professor/early-stage investigator in Pediatrics, Developmental Biology and Immunology at the University of Pittsburgh School of Medicine, Liza Konnikova's focus is on the development of neonatal immunity at mucosal surfaces and its role in the pathogenesis of diverse diseases such as sepsis, preterm labor, necrotizing enterocolitis and very-early onset IBD (VEO-IBD). Her postdoctoral training focused on the development of gastrointestinal (GI) tolerance in children. Through collaborative initiatives, she has shown that a novel subtype of regulatory T-cells exists in the human GI tract and is important in controlling Th17. In Dr. Konnikova's studies of the role of IL10 signaling in mucosal immune development, she has demonstrated that IL10R-deficient patients develop a profound increase in pro-inflammatory cytokines such as IL1b and IL17.

She has pioneered the application of mass cytometry to frozen mucosal biopsies, helping to improve our understanding of mucosal immunity. This innovation has helped to identify novel populations of immune cells in VEO-IBD and to perform serial monitoring of IBD activity in drug trials. In addition to continuing studies on GI immune development in infants and young children, her lab is applying these techniques to gain a better understanding of placental immune development and postulates that there are potential infection-independent immune triggers in the placenta that induce preterm labor and set up a pro-inflammatory cascade in the infants.

Visit Dr. Konnikova's lab website.

View Dr. Konnikova's full list of publications from PubMed.

Patient Comments

Patient comments are gathered from our Press Ganey Patient Satisfaction Survey and are displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

Total Comments:

SHOW ALL COMMENTS+