Research Program

The first year of neurology training includes 8 weeks of research time that will serve as a starting point for a research project that is to be completed by graduation. The division chief, program directors, Director of Clinical Research and program faculty are available to help guide residents in their selections of mentors and projects. Opportunities for clinical research within the Division of Child Neurology include projects in epilepsy, headache, inflammatory nervous symptom disease, metabolism, neuro-genetics, neuroimaging, neuromuscular disorders and childhood stroke as well as projects from other affiliated departments.

The Research Program includes a monthly seminar series designed to teach fundamental approaches for basic and clinical research, and to provide a venue for the residents to present and discuss the findings of their projects. Residents are encouraged to prepare their projects for presentation at national meetings and for publication. 

Neurology Research Studies

Learn more about the researchers in the Division of Child Neurology and our clinical studies

Current Child Neurology Research Studies


  • Expanded access study on the effect of pharmaceutical grade Cannabidiol (CBD) in children with intractable epilepsy (Sogawa)
  • Neural plasticity and recovery of visual functions in patients with hemispherectomy (Patterson)
  • Regional Approaches to Improve Access to Services for Children with Epilepsy (Asato)
  • Established Status Epilepticus Treatment Trial (Sogawa)
  • Prospective observational study of epileptic encephalopathy (Sogawa)
  • A study on the impact of early genetic testing in infantile onset epilepsy (Sogawa)
  • Pediatric Epilepsy Research Consortium (PERC). (Sogawa, Patterson, Rajan)


  • A Phase 1 Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of a Single Dose of SRP-5051 in Patients with Duchenne Muscular Dystrophy Amenable to Exon 51 Skipping Treatment. (Abdel-Hamid)
  • An Open-Label Extension Study for Patients with Duchenne Muscular Dystrophy Who Participated in Studies of SRP-5051 (Abdel-Hamid)
  • An Open-Label, Safety Study for Previously Treated Ataluren (PTC124) Patients with Nonsense Mutation Dystrophinopathy (Abdel-Hamid)
  • An Open-Label, Multi-Center, 48-Week Study with a Concurrent Untreated Control Arm to Evaluate the Efficacy and Safety of Eteplirsen in Duchenne Muscular Dystrophy (Abdel-Hamid)
  • A 48-Week, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Efficacy and Safety of SRP-4045 and SRP-4053 in Patients with DMD (Abdel-Hamid)


  • Neurogenetics Program Patient Registry: Clinical and Genetic Diagnosis, Natural History Study, Translational Research and Biorepository (Rajan)
  • Functional characterization of GEMIN5 - Establishing an gene discovery pipeline from variants of unknown significance on next generation sequencing (Rajan, Pandey)


  • Effects of AFQ056 on Language Learning in Young Children with Fragile X Syndrome (FXS) (Filipink)
  • Fragile X Clinical and Research Consortium (FXCRC) Registry (FORWARD)
  • LEND: The UCLID CENTER at the University of Pittsburgh-LEND Training Outcomes Study (Asato, Noll)

Behavioral Health

  • Non-inferiority trial of Bright IDEAS Problem-Solving Skills Training (PSST) comparing face-to-face PSST to a recently developed electronic version (ePSST) for caregivers of children diagnosed with cancer (Noll)
  • Dissemination science trial (R25e) to train 200 psychosocial professionals (psychologists, social workers, advanced practice nurses) who work in pediatric oncology centers how to deliver PSST (Noll)
  • To assess children enrolled on the current COG high-risk ALL phase 3 trial with computerized assessment tools and standardized psychoeducational tools over time to determine if early pharmacologic or behavioral interventions mitigate psychological problems (Noll)
  • Pilot feasibility trial of Bright IDEAS PSST in pediatric rehabilitation medicine
  • Two site pilot feasibility trial of Bright IDEAS PSST in pediatric sickle cell disease (SCD) clinic


  • Acute Demyelinating Disorders of Childhood (ADEM) (Alper)
  • Acute brain stem clinical and radiological syndromes in children (Thakkar)
  • Neuropsychological outcomes in immune mediated brain disorders (Thakkar)

Stroke and Headache

  • Regional Coordinating Stroke Center of Stroke Trials Network (NINDS) (Cummings)


  • Brainstem presentation of pediatric MS (Shelton, Alper, Zuccoli)

Basic Science

  • Cellular and Molecular Mechanisms of FUS-related neurodegeneration (Pandey)
  • Molecular Basis of FUS/TLS-related amyotrophic lateral sclerosis (Pandey)
  • Molecular library screen for suppressors of FUS proteinopathy (Pandey)
  • A Drosophila model to investigate the role of FUS in ALS (Pandey)
  • Role of RAN peptides in polyQ-independent toxicity in a new C. elegans model for Huntington’s disease (Lamitina)
  • Characterization of modifiers of C9orf72-associated dipeptide toxicity in a new C. elegans model (Lamitina)
  • Functional neurologic consequences of in utero cannabinoid exposure (Franks)
  • Viral immunotherapy to eradicate subclinical brain metastases (Bergman)