Bracing in Adolescent Idiopathic Scoliosis Trial (BrAIST)

The Use of Thoracolumbosacral Orthosis in the Treatment of Adolescent Idiopathic Scoliosis

Protocol Description

This multi-center research study will assess the effectiveness of wearing a brace as treatment for Adolescent Idiopathic Scoliosis (AIS), a curvature in the spine with no clear underlying cause. Although bracing is currently the standard of care for preventing curve progression and treating AIS, researchers believe more can be learned about its effectiveness. This study will compare the risk of curve progression in adolescents with AIS who wear a brace versus those who do not and determine whether there are reliable factors that can predict the usefulness of bracing for a particular individual with AIS.


Eligibility Criteria

Subject to certain screening criteria, boys and girls between 10 and 15 years of age who have been diagnosed with AIS are eligible.
Boys: Ages 10 to 15
Girls: Ages 10 to 15

Through randomized controlled selection, patients will either be assigned to wear a brace or not. Participants who wear a brace will be instructed to use it at least 18 hours per day. Both groups will undergo screening procedures and ongoing standard scoliosis exams and X-rays to determine changes every 6 months. Additionally, braced participants will require additional visits for initial bracing and subsequent adjustments.
Visits: No less than 6
Duration: Approximately 3 years

Status: Open for Enrollment

Sources of Support
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Children’s Miracle Network
Canadian Institute of Health Research
Shriners’ Hospitals for Children 

Additional Resources
Study Description at National Institutes of Health

Primary Investigator(s)

W. Timothy Ward, MD

Contact Information

To get started, please contact:
Joanne A. Londino, RN, BSN

Last Update
January 2, 2014
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Last Update
January 2, 2014