Cancer Care at Children's Hospital of Pittsburgh of UPMC

U.S. News Best Children's Hospital Cancer 2015-2016

The Division of Pediatric Hematology/Oncology at Children’s Hospital is the largest, most comprehensive childhood cancer and blood disease center in western Pennsylvania, eastern Ohio, and northern West Virginia.

Our experts diagnose and treat children and adolescents with all forms of cancer and blood disorders.

Children's Hospital of Pittsburgh of UPMC is a full member of the Children’s Oncology Group (COG) — the world’s largest group devoted to childhood cancer research. This allows us to enter our cancer patients in nearly 100 active clinical trials — studies of the most promising and newest cancer treatments.

Big News!

On June 4, 2014, Children's Hospital of Pittsburgh Foundation announced that it has received a $2.5 million gift from the Mario Lemieux Foundation to establish a new center for rare and hard-to-treat lymphomas that is expected to benefit children and young adults from around the world. Read the full news release about the Mario Lemieux Lymphoma Center for Children and Young Adults at Children's Hospital of Pittsburgh of UPMC.



Clinical Studies

Linda McAllister, MD, PhD

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Cheryl Hillery, MD

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Peter Shaw, MD

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Debra Cohen, MD

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James Cooper, MD

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Melvin Deutsch, MD

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Erika Friehling, MD

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James Graves, PhD, MD

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Lynn Malec, MD

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Gary Mason, MD

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Scott Maurer, MD

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Amma Owusu-Ansah, MD

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Edward Prochownik, MD, PhD

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A. Ritchey, MD

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Jean Tersak, MD

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Randy Windreich, MD

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Michael Wollman, MD

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  • Hematology/Oncology and Blood and Marrow Transplantation

    Children's Hospital of Pittsburgh of UPMC
    4401 Penn Avenue
    Floor 9
    Pittsburgh PA, 15224

  • Specialty Care Center Hermitage

    875 North Hermitage Rd.
    Hermitage PA, 16148

  • Sickle Cell Program

    Children's Hospital of Pittsburgh of UPMC
    4401 Penn Avenue
    Floor 9
    Pittsburgh PA, 15224

  • Acute Lymphoblastic Leukemia and B-Lineage Lymphoma Treatment via Risk-Adapted Chemotherapy – Phase III

    Risk-Adapted Chemotherapy in Treating Younger Patients with Newly Diagnosed Standard-Risk B-Acute Lymphoblastic Leukemia or localized B-Lineage Lymphoblastic Lymphoma Read more

    Acute Lymphoblastic Leukemia Cell Banking Study

    Proper Protocols for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens Read more

    Acute Myeloid Leukemia trial using Bortezomib and Sorafenib – Phase III

    Trial for Patients with de novo Acute Myeloid Leukemia using Bortezomib and Sorafenib for Patients with High Allelic Ratio FLT3/ITD Read more

    Brain Tumor Memory Study – Phase II

    Trial of Modafinil to Improve Neurocognitive Deficits in Children Treated for a Primary Brain Tumor Read more

    Central Nervous System Tumor Treatment with PD-0332991 – Phase I

    A Study of CDK 4-6 Inhibitor PD-0332991 in Children with Recurrent, Progressive or Refractory Central Nervous System Tumors Read more

    Craniopharyngioma Treatment with PEGIntron – Phase II

    Study of Peginterferon alfa-2b (PEGIntron) for Pediatric Patients with Unresectable or Recurrent Craniopharyngioma Read more

    DIPG Treatment with MK-1775 and Local Radiation – Phase I

    MK-1775 and Local Radiation Therapy in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas Read more

    Ependymoma Treatment with Maintenance Chemotherapy – Phase III

    Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Read more

    Ependymoma Vaccine Trial – Pilot

    Treatment for Recurrent Ependymomas in Children Using HLA-A2 Restricted Tumor Antigen Peptides in Combination With Imiquimod Read more

    Ewing Sarcoma Tissue Banking Study

    A Children’s Oncology Group Protocol for Collecting and Banking Ewing Sarcoma Specimens Read more

    Glioma Treatment with Selumetinib (AZD6244) – Phase II

    Pharmacokinetic Study of AZD6244 for Recurrent or Refractory Pediatric Low Grade Glioma Read more

    Glioma Treatment with Veliparib, Radiation and Temozolomide – Phase I/II

    ABT-888, an Oral Poly (ADP-ribose) Polymerase Inhibitor, and Concurrent Radiation Therapy, Followed by ABT-888 and Temozolomide, in Children with Newly Diagnosed Diffuse Pontine Gliomas Read more

    Gliomas Vaccine Study – Pilot

    Treatment of Newly Diagnosed Brainstem Gliomas and Non-Brainstem High-Grade Gliomas, Recurrent Low-Grade and High-Grade Gliomas Read more

    High-Risk Acute Lymphoblastic Leukemia Treatment with Combination Chemotherapy – Phase III

    Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia, Testing Clofarabine in the Very High Risk Stratum Read more

    Hodgkin Disease Banking Study

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    Hodgkin Lymphoma Treatment with Brentuximab Vendotin and Gemcitabine – Phase I/II

    Brentuximab Vedotin in Combination with Gemcitabine for Pediatric and Young Adult Patients with Relapsed or Refractory Hodgkin Lymphoma Read more

    Medulloblastoma and PNET Therapies with Temozolomide, Irinotecan, and Bevacizumab – Phase II

    Temozolomide with Irinotecan versus Temozolomide, Irinotecan plus Bevacizumab for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG Randomized Phase II Screening Trial Read more

    Medulloblastoma Treatment with Carboplatin and Isotretinoin – Phase III

    Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients Read more

    M0 Medulloblastoma Treatment in Very Young Children – Phase I

    Study of Eribulin Mesylate, a Novel Microtubule Targeting Chemotherapeutic Agent, in Children with Refractory or Recurrent Solid Tumors including Lymphomas Read more

    M0 Medulloblastoma Treatment in Young Children – Phase II

    Study for the Treatment of Non-Metastatic Nodular Desmoplastic Medulloblastoma in Children Less Than 4 Years of Age Read more

    Neuroblastoma Biology Studies

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    Osteosarcoma Tissue Banking Study

    A Children’s Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens Read more

    Pediatric Thrombophilia Registry

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    Pediatric Tumors and Specimen Study

    A Children’s Oncology Group Protocol for Collecting and Banking Pediatric Specimens Including Rare Pediatric Tumors Read more

    Plexiform Neurofibromas Treatment with PEG-Intron - Phase II

    Peginterferon alfa-2b in Treating Young Patients with Unresectable, Sympotomatic or Life-Threatening Plexiform Neurofibromas Associated with Neurofibromatosis Type 1 Read more

    Renal Tumors Classification, Biology and Banking Study

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    Sickle Cell Acute Chest Syndrome Treatment with Prasugrel – Phase III

    A Comparison of Prasugrel and Placebo in Pediatric Patients with Sickle Cell Disease Read more

    Sickle Cell Disease Treatment with BMT and Conditioning (STRIDE) – Phase II

    A Study of Hematopoietic Stem Cell Therapy for Young Adults with Severe Sickle Cell Disease Read more

    Sickle Cell Medication Management Study

    Patient-Centered Comprehensive Medication Adherence Management System to Improve Effectiveness of Disease Modifying Therapy with Hydroxyurea in Patients with Sickle Cell Disease Read more

    Sickle Cell Pain Crisis Management Study (SUSTAIN) – Phase II

    Study to Assess Safety and Efficacy of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients with Sickle Cell-Related Pain Crises (SUSTAIN) Read more

    Sickle Cell Vaso-Occlusive Pain Crisis Treatment Study (EPIC) – Phase II

    Evaluation of Purified Poloxamer 188 (MST 188) in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC) Read more

    Solid Tumor and Lymphoma Treatment with PF-02341066 – Phases I and II

    PF-02341066, an Oral Small Molecule Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-MET, in Children with Relapsed/Refractory Solid Tumors and Anaplastic Large Cell Lymphoma Read more

    Solid Tumor or ALCL Treatment with Crizotinib and Conventional Chemotherapy – Phase I

    Crizotinib in Combination with Conventional Chemotherapy for Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Read more

    T-cell Lymphoblastic Leukemia and Lymphoma Treatment with Bortezomib – Phase III

    Bortezomib on a Modified Augmented BFM (ABFM) Backbone in Newly Diagnosed T-Lymphoblastic Leukemia (T-ALL) and T-Lymphoblastic Lymphoma (T-LLy) Read more

    Transient Myeloproliferative Disorder Blood Study

    Biology Study of Transient Myeloproliferative Disorder in Children with Down Syndrome Read more

    Veno-Occlusive Disease Treatment with Defibrotide

    Defibrotide for Treatment of Veno-Occlusive Disease of the Liver Read more

    Wilms Tumor Treatment with Combination Chemotherapy and Surgery – Phase III

    Treatment for Patients with Bilateral, Multicentric, or Bilaterally-Predisposed Unilateral Wilms Tumor Read more