Cancer Care at Children's Hospital of Pittsburgh of UPMC

The Division of Pediatric Hematology/Oncology at Children’s Hospital is the largest, most comprehensive childhood cancer and blood disease center in western Pennsylvania, eastern Ohio, and northern West Virginia.

Our experts diagnose and treat children and adolescents with all forms of cancer and blood disorders.

Children's Hospital of Pittsburgh of UPMC is a full member of the Children’s Oncology Group (COG) — the world’s largest group devoted to childhood cancer research. This allows us to enter our cancer patients in nearly 100 active clinical trials — studies of the most promising and newest cancer treatments.

Big News!

On June 4, 2014, Children's Hospital of Pittsburgh Foundation announced that it has received a $2.5 million gift from the Mario Lemieux Foundation to establish a new center for rare and hard-to-treat lymphomas that is expected to benefit children and young adults from around the world. Read the full news release about the Mario Lemieux Lymphoma Center for Children and Young Adults at Children's Hospital of Pittsburgh of UPMC.

Doctors

Locations

Clinical Studies

  • Hematology/Oncology and Blood and Marrow Transplantation

    Children's Hospital of Pittsburgh of UPMC
    4401 Penn Avenue
    Floor 9
    Pittsburgh, PA 15224
    412-692-5055
  • Specialty Care Center Hermitage

    875 North Hermitage Rd.
    Hermitage, PA 16148
    724-347-4596
  • Sickle Cell Program

    Children's Hospital of Pittsburgh of UPMC
    4401 Penn Avenue
    Floor 9
    Pittsburgh, PA 15224
    412-692-5055
  • Children's South

    205 Millers Run Road
    Bridgeville, PA 15017
    412-854-5005
  • Acute Lymphoblastic Leukemia and B-Lineage Lymphoma Treatment via Risk-Adapted Chemotherapy – Phase III

    Risk-Adapted Chemotherapy in Treating Younger Patients with Newly Diagnosed Standard-Risk B-Acute Lymphoblastic Leukemia or localized B-Lineage Lymphoblastic Lymphoma

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    Acute Lymphoblastic Leukemia Cell Banking Study

    Proper Protocols for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens

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    Acute Myeloid Leukemia trial using Bortezomib and Sorafenib – Phase III

    Trial for Patients with de novo Acute Myeloid Leukemia using Bortezomib and Sorafenib for Patients with High Allelic Ratio FLT3/ITD

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    Acute Promyelocytic Leukemia Treatment using Arsenic Trioxide and All Trans-Retinoic Acid – Phase III

    Study for Patients with Newly Diagnosed Acute Promyelocytic Leukemia using Arsenic Trioxide and All Trans-Retinoic Acid

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    Anaplastic Large Cell Lymphoma Treatment with Brentuximab Vedotin or Crizotinib – Phase II

    Brentuximab Vedotin or Crizotinib in Combination with Chemotherapy for Newly Diagnosed Patients with Anaplastic Large Cell Lymphoma

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    Brain Tumor Memory Study – Phase II

    Trial of Modafinil to Improve Neurocognitive Deficits in Children Treated for a Primary Brain Tumor

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    Central Nervous System Germ Cell Tumor Treatment with Chemotherapy and Radiation – Phase II

    Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors

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    Central Nervous System Tumor Treatment with PD-0332991 – Phase I

    A Study of CDK 4-6 Inhibitor PD-0332991 in Children with Recurrent, Progressive or Refractory Central Nervous System Tumors

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    Craniopharyngioma Treatment with PEGIntron – Phase II

    Study of Peginterferon alfa-2b (PEGIntron) for Pediatric Patients with Unresectable or Recurrent Craniopharyngioma

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    DIPG Treatment with MK-1775 and Local Radiation – Phase I

    MK-1775 and Local Radiation Therapy in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas

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    Ependymoma Treatment with Maintenance Chemotherapy – Phase III

    Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma

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    Ependymoma Vaccine Trial – Pilot

    Treatment for Recurrent Ependymomas in Children Using HLA-A2 Restricted Tumor Antigen Peptides in Combination With Imiquimod

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    Ewing Sarcoma Tissue Banking Study

    A Children’s Oncology Group Protocol for Collecting and Banking Ewing Sarcoma Specimens

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    Ewing Sarcoma Treatment with Combination Chemotherapy Including Ganitumab – Phase II

    Adding the IGF-1R Monoclonal Antibody Ganitumab to Multiagent Chemotherapy for Patients with Newly Diagnosed Metastatic Ewing Sarcoma

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    Ewing Sarcoma Treatment with Combination Chemotherapy Including Topotecan – Phase III

    Adding Vincristine-topotecan-cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma

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    Gliomas (Low-Grade) Vaccine Study – Phase II

    Vaccinations with HLA-A2-Restricted Glioma Antigen-Peptides in Combination with Poly-ICLC for Children with Recurrent Unresectable Low-Grade Gliomas (LGG)

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    Glioma Treatment with Selumetinib (AZD6244) – Phase II

    Pharmacokinetic Study of AZD6244 for Recurrent or Refractory Pediatric Low Grade Glioma

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    Glioma Treatment with Veliparib, Radiation and Temozolomide – Phase I/II

    ABT-888, an Oral Poly (ADP-ribose) Polymerase Inhibitor, and Concurrent Radiation Therapy, Followed by ABT-888 and Temozolomide, in Children with Newly Diagnosed Diffuse Pontine Gliomas

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    Gliomas Vaccine Study – Pilot

    Treatment of Newly Diagnosed Brainstem Gliomas and Non-Brainstem High-Grade Gliomas, Recurrent Low-Grade and High-Grade Gliomas

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    High-Risk Acute Lymphoblastic Leukemia Treatment with Combination Chemotherapy – Phase III

    Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia, Testing Clofarabine in the Very High Risk Stratum

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    High-Risk Medulloblastoma Treatment with Chemotherapy and Radiation – Phase III

    Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients

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    Hodgkin Lymphoma Treatment with Brentuximab Vedotin – Phase III

    Study of Brentuximab Vedotin for Newly Diagnosed High-Risk Classical Hodgkin Lymphoma in Children and Adolescents

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    Hodgkin Lymphoma Treatment with Brentuximab Vendotin and Gemcitabine – Phase I/II

    Brentuximab Vedotin in Combination with Gemcitabine for Pediatric and Young Adult Patients with Relapsed or Refractory Hodgkin Lymphoma

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    Medulloblastoma and PNET Therapies with Temozolomide, Irinotecan, and Bevacizumab – Phase II

    Temozolomide with Irinotecan versus Temozolomide, Irinotecan plus Bevacizumab for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG Randomized Phase II Screening Trial

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    Medulloblastoma Treatment with Carboplatin and Isotretinoin – Phase III

    Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients

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    M0 Medulloblastoma Treatment in Very Young Children – Phase I

    Study of Eribulin Mesylate, a Novel Microtubule Targeting Chemotherapeutic Agent, in Children with Refractory or Recurrent Solid Tumors including Lymphomas

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    M0 Medulloblastoma Treatment in Young Children – Phase II

    Study for the Treatment of Non-Metastatic Nodular Desmoplastic Medulloblastoma in Children Less Than 4 Years of Age

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    Non-Hodgkin Lymphoma or B-Cell Leukemia Evaluation of Rituximab– Phase II/III

    Intergroup Trial for Children or Adolescents with B-cell Non-Hodgkin Lymphoma or Mature B-cell Leukemia: Evaluation of Rituximab Efficacy and Safety in High Risk Patients

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    Osteosarcoma Response to Dinutiximab and Sargramostim – Phase II

    Human-Mouse Chimeric Anti-Disialoganglioside Monoclonal Antibody ch14.18 (Dinutuximab) in Combination with GM-CSF (Sargramostim) in Patients with Recurrent Osteosarcoma

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    Osteosarcoma Tissue Banking Study

    A Children’s Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens

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    Pediatric Tumors and Specimen Study

    A Children’s Oncology Group Protocol for Collecting and Banking Pediatric Specimens Including Rare Pediatric Tumors

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    Pilocytic Astrocytoma and Optic Pathway Glioma Treatment with Lenalidomide – Phase II

    Trial of Lenalidomide in Pediatric Patients with Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas

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    Plexiform Neurofibromas Treatment with PEG-Intron - Phase II

    Peginterferon alfa-2b in Treating Young Patients with Unresectable, Sympotomatic or Life-Threatening Plexiform Neurofibromas Associated with Neurofibromatosis Type 1

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    Sickle Cell Acute Chest Syndrome Treatment with Prasugrel – Phase III

    A Comparison of Prasugrel and Placebo in Pediatric Patients with Sickle Cell Disease

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    Sickle Cell Disease Treatment with BMT and Conditioning (STRIDE) – Phase II

    A Study of Hematopoietic Stem Cell Therapy for Young Adults with Severe Sickle Cell Disease

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    Sickle Cell Medication Management Study

    Patient-Centered Comprehensive Medication Adherence Management System to Improve Effectiveness of Disease Modifying Therapy with Hydroxyurea in Patients with Sickle Cell Disease

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    Sickle Cell Pain Crisis Management Study (SUSTAIN) – Phase II

    Study to Assess Safety and Efficacy of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients with Sickle Cell-Related Pain Crises (SUSTAIN)

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    Sickle Cell Vaso-Occlusive Pain Crisis Treatment Study (EPIC) – Phase II

    Evaluation of Purified Poloxamer 188 (MST 188) in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC)

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    Soft Tissue Sarcoma Treatment with Preoperative Radiation and Pazopanib (PAZNTIS Trial) – Phase II/III

    Pazopanib Neoadjuvunt Trial on Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib

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    Solid Tumor and Lymphoma Treatment with PF-02341066 – Phases I and II

    PF-02341066, an Oral Small Molecule Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-MET, in Children with Relapsed/Refractory Solid Tumors and Anaplastic Large Cell Lymphoma

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    Solid Tumor or ALCL Treatment with Crizotinib and Conventional Chemotherapy – Phase I

    Crizotinib in Combination with Conventional Chemotherapy for Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma

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    Solid Tumor Treatment with MK-1775 – Phase I/II

    MK-1775 in Combination with Oral Irinotecan in Children, Adolescents, and Young Adults with Relapsed or Refractory Solid Tumors

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    Solid Tumor Treatment with Ramucirumab – Phase I

    A Study of Ramucirumab, a Human Monoclonal Antibody Against the Vascular Endothelial Growth Factor-2 Receptor in Children with Refractory Solid Tumors, Including CNS Tumors

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    T-cell Lymphoblastic Leukemia and Lymphoma Treatment with Bortezomib – Phase III

    Bortezomib on a Modified Augmented BFM (ABFM) Backbone in Newly Diagnosed T-Lymphoblastic Leukemia (T-ALL) and T-Lymphoblastic Lymphoma (T-LLy)

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    Transient Myeloproliferative Disorder Blood Study

    Biology Study of Transient Myeloproliferative Disorder in Children with Down Syndrome

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    Tumor and Acute Lymphoblastic Leukemia Treatment with BMN 673 and Temozolomide – Phase I/II

    BMN 673, an Oral Poly Polymerase Inhibitor, Plus Temozolomide in Children with Refractory or Recurrent Malignancies

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    Tumor Treatment with Nivolumab with and without Ipilimumab – Phase I/II

    Nivolumab in Children, Adolescents, and Young Adults with Recurrent or Refractory Solid Tumors as a Single Agent and in Combination with Ipilimumab

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    Wilms Tumor Treatment with Combination Chemotherapy and Surgery – Phase III

    Treatment for Patients with Bilateral, Multicentric, or Bilaterally-Predisposed Unilateral Wilms Tumor

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