Kasai Procedure Study

Protocol Description

The primary purpose of this study is to gather information on children with biliary atresia so that researchers will be able to learn more about what happens to patients after they have had the Kasai procedure to improve the bile flow. Investigators also hope to learn more about the causes of biliary atresia. In addition, blood and urine samples collected from children participating in the study will be used in future research about liver disease.

This study is being conducted through the Childhood Liver Disease Research and Education Network (ChiLDREN), a network of 15 clinical sites in the United States and Canada.

Eligibility Criteria

Children and young adults 1 year of age and older who have a diagnosis of biliary atresia and have had a Kasai procedure performed are eligible to take part in this study. Patients are eligible for the study regardless of whether they have had a liver transplant, and study participants will include males and females of all racial and ethnic groups.
Boys: 1 and over
Girls: 1 and over

Study participants will be seen in the research clinic once a year for 5 years or until they have a liver transplant. Each clinic visit will include a physical examination, as well as the collection of blood and urine samples. Biological parents will also be asked to provide a blood sample for research purposes. If a study participant undergoes a liver transplant during the course of the study, tissue samples from the liver that was removed and not needed for clinical purposes will be collected for research. If a study participant has already had a liver transplant, a single visit will constitute the study and will include a physical examination, review of past medical history, including family history and collection of a blood sample from the participant and biological parents.
Visits: 5
Duration: 5 years

Status: Open for Enrollment

Source of Support
National Institutes of Health

Contact Information

For more information about this study or enrollment, please contact:
Kathy Bukauskas, RN, CCRC

Last Update
January 27, 2015
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Last Update
January 27, 2015