Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Download our mobile app today - it's free!
This multicenter trial by the Children’s Oncology Group compares how well combination chemotherapy works when given with or without bortezomib in treating patients with newly diagnosed T-cell acute lymphoblastic leukemia (T-ALL) or stages II through IV T-cell lymphoblastic lymphoma (T-LLy). Bortezomib may help reduce the number of leukemia or lymphoma cells by blocking some of the enzymes needed for cell growth. It may also enhance chemotherapy by making cancer cells more sensitive to the drugs. Another goal of the study is to see if cranial radiation therapy can be safely removed from treatment for most patients.
Subject to certain exclusion criteria, this study is open to males and females, ages 2 to 30 years, who have newly diagnosed T-ALL or T-LLy.
Males and Females: Ages 2 to 30 years
Study participants will be randomly assigned to one of two groups. One will be given standard chemotherapy treatment. The other will receive standard chemotherapy with the addition of intravenous treatments of bortezomib at certain stages of therapy. Additionally, cranial radiation therapy will be given only to participants with high-risk T-ALL or intermediate-risk T-ALL with signs of leukemia in spinal fluid or the central nervous system.
Visits: The same number of visits as required for standard therapy
Duration: Approximately 2-1/2 to 3 years
Children’s Oncology Group (AALL1231)
National Cancer Institute
Jean M. Tersak, MD
For more information about the study or enrollment, please contact:
Jean M. Tersak, MD
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.