The Division of Pediatric Pathology provides diagnostic and consultative services for surgical specimens, biopsy and cytologic specimens. The service also includes electron microscopy. Other clinical pathology services are listed by specific laboratory. All specimens for examination must be submitted with the appropriate clinical information. Pathologists are available to consult on how to take and preserve specimens. Pathological material from outside the hospital also will be reviewed upon request, provided proper arrangements have been made prior to receipt of the specimen. The Division of Pediatric Pathology also conducts postmortem examinations.

Staff interests cover all areas of pediatric diagnostic pathology. A range of special procedures applicable to pediatric surgical pathology is offered. Special handling is required for some procedures.

Areas of Interest and Expertise

  • Pediatric liver diseases
  • Pediatric transplant pathology: liver, small bowel, heart, lung and kidney
  • Epstein-Barr virus-related diseases
  • Pediatric solid and soft tissue tumors (including, but not limited to, Ewing’s sarcoma/primitive neuroectodermal tumor, rhabdomyosarcoma, neuroblastoma, Wilms tumor and lymphoma)
  • Pediatric brain tumors (glioblastomas, astrocytomas)
  • Histiocytosis and dendritic cell diseases, including Langerhans cell histiocytosis
  • Molecular diagnosis of pediatric infectious diseases
  • Pediatric heart disease

Special Procedures

  • Immunohistochemistry, including immunostaining and immunofluorescence, with special panels applicable to pediatric diseases
  • Electron microscopy for tumors, metabolic disorders, muscle diseases, renal diseases and ciliary dysfunction
  • In situ hybridization for Epstein-Barr virus
  • Acetylcholinesterase histochemistry and detection of peptides relevant to Hirschsprung’s disease and motility disorders
  • Polymerase chain reaction-based assays for Bordetella pertussis and Chlamydia trachomatis



Miguel Reyes-Mugica, MD

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Sarangarajan Ranganathan, MD

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Amy Davis, MD

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Steven Dobrowolski, PhD

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John Ozolek, MD

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Jennifer Picarsic, MD

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  • Pathology

    4401 Penn Avenue
    Floor B
    Pittsburgh PA, 15224