Children's Hospital is part of the UPMC family.
Our Sites
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Ranked #8 Nationally by U.S. News & World Report.
Byler disease is an inherited condition caused by a faulty gene.
In children with Byler disease, cells in the liver can’t release bile — a fluid that helps the body digest food. As a result, bile builds up in the liver, causing symptoms such as jaundice, itching, impaired growth, and delayed puberty.
Byler disease is one of a group of diseases known as progressive familial intrahepatic cholestasis.
Children are often around 3 months old when diagnosed with Byler disease.
If your child has Byler disease, we want you to know you’re not alone. The Center for Rare Disease Therapy (CRDT) at UPMC Children's Hospital of Pittsburgh is here to help.
To make an appointment for your child or refer a patient for Byler disease care, contact us by:
Here’s what you can expect when you come to us for a consult.
We’ll schedule an appointment with one of our children’s liver doctors within a reasonable time based on your child’s condition.
We’ll need a copy of your child's medical records before your first visit.
Looking over your child's records helps us:
Your first visit will take about 3 to 4 hours.
Your child will receive a complete assessment to confirm or make a precise Byler disease diagnosis. We’ll also check to see how much the disease has affected your child.
Since we work as a team, other doctors might see your child on the first or on follow-up visits.
These may include a:
Before the end of your visit, we will:
You’ll also meet our clinical nurse practitioner who will be your point of contact between now and your next appointment. You can contact them by phone or video conference about any concerns you have.
Before you leave, please ask us any questions you have about your child’s Byler disease diagnosis or treatment.
It depends on the types of tests your child had during your visit.
In most cases, we’ll call you within 2 weeks to explain test results and discuss recommended next steps.
You can also access your child’s test results on Children's patient portal, MyCHP. It’s free for our patients, parents, and guardians.
When a child has a rare health problem like Byler’s disease, it affects the whole family.
At the Center for Rare Disease Therapy, we see each family member as our partner in caring for their child.
The best care plans happen when we combine our rare disease knowledge with your expertise in your child’s needs.
Learn how others are finding help and hope for their child’s rare disease through the expertise at UPMC Children’s.
View Center for Rare Disease Therapy patient stories »
At the CRDT, every child diagnosed with a rare disease receives a tailored treatment plan and family-centered care.
For an appointment, consult, or referral, contact us:
We’ll be in touch within 2 business days.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With MyCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.