Muromonab-CD3 (Orthoclone OKT3®)


Muromonab CD3 is also referred to as OKT3.


Muromonab CD3 (Orthoclone OKT3®) is an immunosuppressant drug used to reduce the natural immunity of patients who receive organ transplants such as liver transplants.


Muromonab CD3 is a monoclonal antibody that prevents white blood cells from causing organ rejection.

Types Available

Muromonab CD3 is a liquid that is given by injection.

Side Effects

Common side effects of muromonab CD3 include:

  • Increased risk of infection. You can help to prevent infection by making sure your child avoids contact with people who are ill.
  • Reduction in the number of blood cells needed for clotting. To prevent bleeding, avoid situations where bruising or injury might occur.
  • Chest pain, dizziness, fever and chills, shortness of breath, stomach upset, and trembling or shaking of the hands within a few hours after taking the first dose. These effects should lessen substantially after the second dose and should not occur after that.

Other common side effects of muromonab CD3 include:

  • diarrhea
  • faintness
  • headache
  • nausea
  • vomiting
  • rapid heartbeat

Rare side effects of muromonab CD3 include:

  • stiff neck
  • light sensitivity
  • confusion
  • hallucinations
  • unusual tiredness

If any of these side effects continues or becomes bothersome, inform your child's doctor.

Drug Interactions

Tell your transplant doctor or pharmacist about any prescription or over-the-counter medication that you are taking, so you can be warned of interactions and prevent them.

Learn more about other Intestine Transplant Drugs.