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Through this study researchers hope to determine which of the many Eustachian tube function tests or combination of tests is most helpful in determining the cause of ear problems in children and adult patients with middle ear diseases thought to be due to poor Eustachian tube function.
Subject to exclusion criteria, the study is accepting healthy individuals of both genders, including those ages 3 to 70 years who have diagnosed or suspected Eustachian tube dysfunction or middle ear disease and those ages 18 to 60 years who have no history of disease caused by Eustachian tube dysfunction.
Males and Females: Ages 3 to 70
Participants will be seen by investigators once if they have Eustachian tube dysfunction and twice if they do not. Each visit will take about 4 hours. Initially, participants will have medical history review and a physical examination. Ears will be examined by otoscopy, and ear pressure will be measured by tympanometry. Among other tests to be performed are: sonotubometry, tubomanometry, maneuver sequence, and video nasal endoscopy. Additional tests will be performed, dependent on whether participants have an intact eardrum or a hole or tympanostomy tube in the eardrum. Investigators will follow up by telephone 4 times over 2 years with the participants who have Eustachian tube dysfunction.
Visits: 1 or 2, depending on diagnosis
Duration: Up to 2 years for those with Eustachian tube dysfunction
National Institutes of Health
Study Description at National Institutes of Health
Otolaryngology (ENT) Research
Cuneyt M. Alper, MD
For more information about the study or enrollment, please contact:
Julie Banks, Research Coordinator
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Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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