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The Division of Pediatric Otolaryngology at UPMC Children’s Hospital of Pittsburgh has an extensive research program that began in 1975 and has since become “the place” for the treatment of otitis media, which includes ear infections and fluid build-up in the middle ear. No institution has done more to shed light on the pathogenesis of otitis media and point the way toward improved therapies than Children’s. Our clinical Ear, Nose and Throat (ENT) Research Center, Middle Ear Physiology Laboratory, and Basic Research Laboratory are engaged in numerous clinical and laboratory studies investigating the causes, development, and management of middle ear disease, as well as other pediatric ear, nose, and throat disorders.
One of the facets that makes Children’s ENT research program unique is the Middle Ear Physiology Laboratory in Oakland, which has a special pressure chamber that allows researchers to study the middle ear system without having a perforation in the eardrum, as with earlier methods. The chamber, which simulates pressures similar to those experienced underwater as well as on an airplane, was added as part of a $5-million study funded by the National Institutes of Health (NIH) to investigate the cause and treatment of otitis media. Children’s researchers have used this facility to gain better understanding of pediatric and adult middle ear conditions.
In one ongoing study, children enrolled at the age of 3 undergo annual Eustachian tube function testing until they are 7, enabling researchers to measure Eustachian tube development and compare among children with histories of recurrent ear infections or persistent middle ear fluid or no history of significant middle ear disease. Another NIH-funded study investigates whether a small change in the surgical repair of a cleft palate makes a significant difference in decreasing middle ear disease.
Children who are having their eardrums patched are being studied to see whether researchers can predict outcomes through Eustachian tube function testing prior to surgery. Patients being seen by Children’s Aerodigestive Center, who are diagnosed with laryngomalacia (a floppiness of the voice-box) can participate in a quality-of-life study, which may lead to better therapies and ways to improve their treatment experience.
Our researchers are also participating in a multi-center study of the genes and virus involved in an uncommon childhood disease, recurrent respiratory papillomatosis.
Several adult ear studies are also underway. One involves testing Eustachian tube function during a “cold.” Another investigates risk factors, such as allergy and acid reflux, in adults with ear tubes. Adults with ragweed allergies are being enrolled in another study investigating whether nasal challenge with ragweed provokes changes in middle-ear pressure.
Middle Ear Pressure Disregulation in Cleft Palate Patients
Furlow Palatoplasty with Tensor Tenopexy for Otitis Media
Outcomes of Management of Type 1 Laryngeal Cleft (LC-1)
Eustachian Tube Growth and Development: Anatomy/Function
Gas Supply, Demand and Middle Ear Gas Balance, Part 4.3 – Diagnosis of Eustachian Tube Dysfunction
Gas Supply, Demand and Middle Ear Gas Balance, Part 4.2 – Fly/Dive Comparison
Gas Supply, Demand and Middle Ear Gas Balance – Specific Aim 3
Eustachian Tube Function as a Predictor of Myringoplasty/Tympanoplasty Outcome
Adhesion Properties of Middle Ear Effusion
Modulation of Trans-Middle Ear Mucosal Gas Exchange – Project 1, Specific Aim 2
Microbiome of the Paranasal Sinuses in Health and Disease
Microbiome of the Paranasal Sinuses During Adenoidectomy for Recurrent or Chronic Rhinosinusitis
Evaluation of Cytokine IL-22 Levels in Nasal Secretions of Pediatric Cystic Fibrosis Patients
Study to Evaluate the Safety and Efficacy of the Hypoglossal Nerve Stimulator in Adolescents and Young Adults with Down Syndrome and Obstructive Sleep Apnea
Genetics of Papilloma-Induced Voice Disturbance
Multi-institutional Validation of the Clinical Assessment Score-15 for Pediatric Sleep-disordered Breathing
David Schmidt, PhD
J. Douglas Swarts, PhD
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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