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Inflammation originates from many sources, such as infection, trauma, allergy, autoimmunity and more. It manifests in a dizzying array of varieties and combinations that change over time and with treatment. With such complexity, finding solid places to start investigating is challenging. The revolution in high-throughput sequencing has resulted in the identification of an increasing number of monogenic (single-gene) defects associated with excessive inflammation.
Members of the Canna Lab team are currently focused on these subject areas:
A schematic of the mechanisms resulting in systemic macrophage activation. In familial hemophagocytic lymphohistiocytosis (a), cytotoxic lymphocytes lack the ability to kill infected antigen-presenting cells. In macrophage activation syndrome (b), intrinsic defects such as hyperactivity of the NLRC4 inflammasome could prime for macrophage activation directly but could also lead to other outcomes, including cell death.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.