The Coyne Lab for Virus Research

Discovering the Biological Gatekeepers to Virus Spread

Researchers within the laboratory of Carolyn Coyne, PhD, study the pathways by which viruses cross cellular barriers and the mechanisms by which these barriers restrict viral infections. Research primarily focuses on the polarized epithelium that lines the gastrointestinal tract and placental trophoblasts, which comprise the primary cellular barrier of the human placenta. In addition to studying cellular barriers, the Coyne Lab focuses on delineating the pathways targeted by RNA viruses (such as enteroviruses and flaviviruses) to promote their replication and spread. The work is highly multidisciplinary and encompasses aspects of cell biology, tissue engineering, immunology, and microbiology. 

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