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For more information about research, please call our main office at 412-692-6438.
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RNA viruses usurp a variety of host cell pathways to facilitate their replication. One of the key missions of the Coyne Lab is identifying the pathways targeted by RNA viruses (including enteroviruses and flaviviruses) to promote their replication and spread.
An obligate step in the life cycle of positive sense RNA viruses is the formation of membrane-enriched organelles, termed replication organelles, that provide the structural support for viral replication. Multiple mechanisms have been proposed for the generation of these membranes, including manipulation of the host autophagic pathway, a process that removes damaged organelles via the formation of double membrane bound vesicles. Current studies in the laboratory are focused on the identification and characterization of novel regulators of host cell authophagy and on the identification of mechanisms employed by RNA viruses to specifically modulate the host autophagic pathway.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.