Cystic Fibrosis Imaging Study

Imaging Airway Liquid Absorption in Cystic Fibrosis

Protocol Description

The purpose of this study is to develop an aerosol-based nuclear medicine imaging technique that may ultimately help researchers test new medications for people with cystic fibrosis. Many researchers believe that people with cystic fibrosis absorb too much water from the insides of their lungs, leading to the characteristic thick, sticky mucus that causes lung problems for those with the disease. Through this study, researchers will determine how fast water passes from the lungs into the blood after a mist is inhaled. This technique may also provide a measure of disease severity and an indication of therapeutic correction in advance of currently available outcome measures.

Eligibility Criteria

Researchers are enrolling adults and children with cystic fibrosis, as well as adults who do not have cystic fibrosis. Participants must be able to perform repeatable pulmonary function testing and remain still for 90 minutes.  
Males and Females: Ages 6 and older

The study requires 2 visits for nuclear imaging at either Children’s Radiology Department or the Nuclear Medicine Department at Presbyterian Hospital. Participants will be given pulmonary function tests prior to imaging, which will be done before and after inhaling the prescribed test medication, and again after inhaling an isotonic saline solution. The imaging testing will be repeated 22 to 26 months after the initial imaging was done.
Visits: 2
Duration: 2 years

Status: Open for Enrollment

Source(s) of Support
National Institutes of Health

Primary Investigator(s)

Timothy E. Corcoran, PhD

Contact Information

For information or to enroll, please contact:
Elizabeth Hartigan, MPH, RN

Last Update
December 29, 2013
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Last Update
December 29, 2013