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Illness from lung infections is the leading reason children visit doctors in the United States each year. And worldwide, lung infections are the number-one cause of death among children. Recognizing that the susceptibility to respiratory infections is an interplay between microbe and host, researchers at Children’s Hospital of Pittsburgh of UPMC are leading the charge against respiratory illness on multiple fronts: from asthma, pneumonia, bronchitis, cystic fibrosis and tuberculosis to sleep disorders and exotic conditions such as pulmonary lymphangiectasia and plastic bronchitis.
Children’s unique Laboratory of Lung Immunology and Host Defense is investigating the immune response to various lung pathogens. By understanding immune responses that confer protection against infection with damaging the lung, these immune responses can be exploited for novel vaccine approaches or immune-based therapies to prevent or treat lung infections. The lab is internationally known in the area of lung inflammation and Pneumocystis research and is well funded by the National Institutes of Health. It is also a recipient of one of three Specialized Centers of Clinically Oriented Research grants in the area of Host Factors in Chronic Lung Disease.
Investigating the causes and treatment of cystic fibrosis, Children’s Cystic Fibrosis Center is one of the largest of its kind in the country. There, researchers examine lung infection down to the cellular and molecular level to gain a better understanding of how the lungs protect themselves, and then to use this knowledge to develop innovative therapies.
Research into the genetic and environmental causes of asthma and its treatment is a core focus of the Pediatric Asthma Center. Allergy is a common problem in children and the division is advancing novel treatments for asthma and inherited forms of allergy. The outpatient allergy program works collaboratively with the pulmonology program forming a unique multidisciplinary approach to patients with asthma and other allergic pulmonary disease. The prevalence of food allergy has dramatically increased over the last decade and its diagnosis is challenging. The clinical program at Children’s is the only one in the region that provides oral challenges and works collaboratively with gastroenterologists. At Children’s hospital of Pittsburgh, the care for children with allergies, asthma and immunodeficiencies integrates multiple subspecialists to provide optimal care for these patients.
Children’s has one of the nation’s largest bronchoscopy services, which offers technologically advanced pulmonary function testing. Studies to assess upper airway function and the regulatory mechanisms of breathing can be performed on young children and even tiny infants. Today, our understanding of lung infections and diseases is undergoing a revolution, while Children’s well-respected pulmonology and allergy/immunology research teams has emerged as a pioneer in this research.
Epigenetic Variation and Childhood Asthma in Puerto Ricans (EVA-PR)
Stress and Treatment Response in Puerto Rican Children with Asthma (STAR)
Vitamin D to Prevent Severe Asthma Exacerbations (Vit-D-Kids Asthma)
Exposure to Violence, Epigenetic Variation, and Childhood Asthma in Puerto Ricans
Steroids in Eosinophil-Negative Asthma (SIENA)
Biomarkers of Lung Disease in Bronchoalveolar Lavage Fluid
Cough Peak Flow And Airway Clearance in Pediatric Patients with Neuromuscular Disease
Trial to Study the Efficacy and Safety of Viaskin Milk for Treating IgE-Mediated Cow’s Milk Allergy in Children
Participation in the Cystic Fibrosis Patient Registry
Open-label Vitamin D Trial for Patients with Cystic Fibrosis and Allergic Bronchopulmonary Aspergillosis
Effects of Inhaled Bicarbonate on Airway pH in Cystic Fibrosis
Mechanisms of Immune Tolerance and Inflammation in Allergic Bronchopulmonary Aspergillosis (ABPA) in Patients with Cystic Fibrosis
Trial to Assess Peanut Epicutaneous Immunotherapy Efficacy and Safety (PEPITES) with Viaskin Peanut in Peanut-Allergic Children
Peanut Allergy Oral Immunotherapy Study of AR101 for Desensitation in Children and Adults (PALISADE)
Severe Asthma Research Program: Inflammation, Myofibroblasts and Loss of Elastic Recoil in Severe Asthma
The EPIC Observational Study: Long-Term Study of Risk Factors and Impact of Pseudomonas aeruginosa and Early Anti-Pseudomonal Treatment in Children with Cystic Fibrosis
John Alcorn, PhD
Nadia Boutaoui, PhD
Wei Chen, PhD
Yueh-Ying Han, PhD, MS
Jieru Wang, PhD, MS
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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