Inducing Cardiomyocyte Proliferation

Inducing Cardiomyocyte ProliferationThe Kühn Lab has discovered that cell cycle re-entry and division of cardiomyocytes is induced by periostin peptide, a component of the extracellular matrix, and neuregulin 1 (NRG1), a growth factor. After experimentally inducing myocardial infarctions, we have shown that the administration of recombinant periostin peptide or NGR1 enhances cardiomyocyte cycling, reduces infarct size, and improves myocardial function. Using an animal model to mimic heart failure in babies and children, we are currently testing the therapeutic benefits of NGR1 administration.

We have demonstrated that a sub-population of differentiated cardiomyocytes has proliferative potential and responds to periostin peptide and NGR1 with cell cycle re-entry.