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One of the key missions of the Division of Pediatric Nephrology of UPMC Children’s Hospital of Pittsburgh is to extend the knowledge of pathophysiology of renal disease through basic laboratory and clinical research.
Key nephrology research includes an investigative focus on nephropathy in type 1 diabetes and in pediatric renal transplantation outcomes. Other areas of interest to Children’s researchers include proteinuria, hypertension, tubulointerstitial nephritis and dysnatremias.
Ongoing extramural grants support the investigation of the genetic epidemiology of urinary tract abnormalities and of the genetic aspects of nephrotic syndrome and of focal glomerulosclerosis. These are all common and important disorders in children. In addition Children’s researchers are conducting a biomarker-based study of BK virus, a polyoma virus, as it relates to renal allograft injury after renal transplantation in childhood.
Other nephrology research involves a study of the basic mechanisms of apoptosis in proximal tubular epithelial cells exposed to albumin to mimic the effect of proteinuric disorders in general.
Rannar Airik, PhD
Sunder Sims-Lucas, PhD
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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