Gastroenterology Research

Researchers at Children’s Hospital of Pittsburgh of UPMC have taken on multiple challenges in gastroenterology disorders. Pancreatitis, liver disease, biliary atresia, and inflammatory bowel disease are just a few of the many areas of focus.

With funding from the National Institutes of Health, Children’s gastroenterology laboratories are leaders in: understanding the physiology of lipases – enzymes that digest fats – and, more specifically, the roles these proteins play in digestion and disease; characterizing the function and regulation of intestinal transporters for water and bile acids; and the pathophysiology and treatment of alpha-1-antitrypsin deficiency, the most common genetic disease of the liver in childhood.

Children’s gastroenterologists also head multiple clinical studies. Liver disease is under assault from Children’s pediatric gastroenterologists working to advance potential therapies that range from increasing our understanding of biliary atresia and acute liver failure, liver diseases often treated with liver transplantation, to transplanting hepatocytes as a possible cure for many childhood liver diseases. Clinical studies in pediatric inflammatory bowel disease are also a focus of Children’s gastroenterology researchers. These studies include participation in local and national registries to gather data about outcome and treatment of children with inflammatory bowel disease and an innovative and novel study to define the role of behavioral therapy in treating children with inflammatory bowel disease.

Children’s gastroenterology research is both local and international in scope, as the hospital has taken a leadership role in establishment of multicenter studies allowing collaboration and information sharing among experts throughout North America and beyond.

Researchers

Clinical Studies

Mark E. Lowe, MD, PhD

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Feras T. Alissa, MD

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Arjumand Ghazi, PhD

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David John Keljo, MD, PhD

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Dale Eugene King, MD

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Sapana J Shah, MD

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Robert H. Squires, MD

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Arvind I. Srinath, MD

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Eva M. Szigethy, MD, PhD

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Veena Lalita Venkat, MD

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Alagille Syndrome and LUM001: The IMAGINE Study – Phase II

Long-term Safety and Durability of the Therapeutic Effect of LUM001, an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI), in the Treatment of Cholestatic Liver Disease in Pediatric Subjects with Alagille Syndrome

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Alpha-1 Antitrypsin Deficiency Study – Phase II

A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1-Antitrypsin Deficiency

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Biliary Atresia Long-Term Observation: The BASIC Study

Biliary Atresia Study in Infants, Children and Adults

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Cholestasis Long-term Observation: The LOGIC Study

Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)

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Cholestasis Natural History Database: The PROBE Study

A Prospective Database of Infants with Cholestasis

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Colon Cleansing with Prepopik Before Colonoscopy – Phases I & II

Study Comparing the Safety and Efficacy of Prepopik versus Polyethylene Glycol Preparation in Children

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Constipation in Patients with IBS Treated with Linaclotide – Phase II

Study of a Range of Linaclotide Doses Administered Orally to Children, Ages 7 to 17 Years with Irritable Bowel Syndrome with Constipation

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Constipation Treatment with Linaclotide – Phase II

Study of a Range of Linaclotide Doses Administered Orally to Children, Ages 6 to 17 Years, Who Fulfill Modified Rome III Criteria for Child/Adolescent Functional Constipation

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Crohn’s Disease - Risk and Microbial Marker Study

Risk Stratification and Identification of Immunogenetic and Microbial Markers of Rapid Disease Progression in Children with Crohn’s Disease

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Crohn’s Disease and Sleep Disturbance Study – Phase IV

Treating Disrupted Sleep in Individuals with Inflammatory Bowel Disease: A Novel Adjunctive Therapy for Chronic Inflammatory Illness

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Crohn's Disease Treatment using Blood Stem Cells – Phase I/II

Autologous Stem Cell Transplantation with CD34 Selected Peripheral Blood Stem Cells (PBSC) in Pediatric and Young Adult Patients with Severe Crohn's Disease

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IBD Treatment with Remicade®: The ADAPT Study – Phase IV

Study of Infliximab in Pediatric Participants with Inflammatory Bowel Disease (ADAPT)

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ICARE Research Registry

Intestinal Care and Rehabilitation Center Database

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Intrahepatic Cholestasis and LUM001: The INDIGO Study – Phase II

Efficacy and Long-term Safety of LUM001, an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTi) in the Treatment of Cholestatic Liver Disease in Pediatric Patients with Progressive Familial Intrahepatic Cholestasis

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Mitochondrial Hepatopathies Long-term Observation: The MITOHEP Study

Longitudinal Study of Mitochondrial Hepatopathies

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Newborn Lipase Fat Digestion Study

Molecular Mechanisms of Dietary Fat Digestion by Pancreatic Lipases – Fecal Fat and Duodenal Fluid Collection Research Studies

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Pancreatitis INSPPIRE Registry

A Study of Acute Recurrent and Chronic Pancreatitis in Children by the International Study Group of Pediatric Pancreatitis In Search of a Cure (INSPPIRE)

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Primary Sclerosing Cholangitis Drug Study – Phase I

Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis: A Pilot Withdrawal/ Reinstitution Trial

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TPN-Related Cholestasis Treatment with Omegaven - Phase II

Compassionate Use of Omegaven in the Treatment of Parenteral Nutrition-Associated Hepatic Injury

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