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Researchers at UPMC Children’s Hospital of Pittsburgh have taken on multiple challenges in gastroenterology disorders. Pancreatitis, liver disease, biliary atresia, and inflammatory bowel disease are just a few of the many areas of focus.
With funding from the National Institutes of Health, Children’s gastroenterology laboratories provide leadership in: understanding the physiology of lipases – enzymes that digest fats – and, more specifically, the roles these proteins play in digestion and disease; characterizing the function and regulation of intestinal transporters for water and bile acids; and the pathophysiology and treatment of alpha-1-antitrypsin deficiency, the most common genetic disease of the liver in childhood.
Children’s gastroenterologists also head multiple clinical studies. Liver disease is under assault from Children’s pediatric gastroenterologists working to advance potential therapies that range from increasing our understanding of biliary atresia and acute liver failure, liver diseases often treated with liver transplantation, to transplanting hepatocytes as a possible cure for many childhood liver diseases. Clinical studies in pediatric inflammatory bowel disease are also a focus of Children’s gastroenterology researchers. These studies include participation in local and national registries to gather data about outcome and treatment of children with inflammatory bowel disease and an innovative and novel study to define the role of behavioral therapy in treating children with inflammatory bowel disease.
Researchers
Clinical Studies
Biliary Atresia Study in Infants, Children and Adults
Study to Evaluate Maralixibat in the Treatment of Subjects with Biliary Atresia after Hepatoportoenterostomy
Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)
A Prospective Database of Infants with Cholestasis
Study to Evaluate Maralixibat in the Treatment of Infants with Cholestatic Liver Diseases Including Progressive Familial Intrahepatic Cholestasis and Alagille Syndrome
Study to Evaluate Vedolizumab Intravenous as Maintenance Therapy in Pediatric Subjects with Moderately to Severely Active Crohn’s Disease Who Achieved Clinical Response Following Open-Label Vedolizumab Intravenous Therapy
Study of Oral Pantoprazole in Pediatric Participants who Require Maintenance Therapy for Healed Erosive Esophagitis
Using Patient Data to Transform Care and Improve Outcomes for Children, Adolescents and Young Adults with Inflammatory Bowel Disease
FibroScan® in Pediatric Cholestatic Liver Disease Study
Longitudinal Study of Mitochondrial Hepatopathies
A 5-year Longitudinal Observational Study of Patients with Nonalcoholic Fatty Liver or Nonalcoholic Steatohepatitis
Pediatric Longitudinal Cohort Study of Chronic Pancreatitis (INSPPIRE 2)
Prospective Observational Study of Primary Sclerosing Cholangitis in Children, a Protocol of the Childhood Liver Disease Research Network
Study to Evaluate Vedolizumab Intravenous as Maintenance Therapy in Pediatric Subjects with Moderately to Severely Active Ulcerative Colitis Who Achieved Clinical Response Following Open–Label Vedolizumab Intravenous Therapy
Arjumand Ghazi, PhD
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
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