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Children's Hospital is ranked One of America's Best Children's Hospitals.
Researchers at Children’s Hospital of Pittsburgh of UPMC have taken on multiple challenges in gastroenterology disorders. Pancreatitis, liver disease, biliary atresia, and inflammatory bowel disease are just a few of the many areas of focus.
With funding from the National Institutes of Health, Children’s gastroenterology laboratories are leaders in: understanding the physiology of lipases – enzymes that digest fats – and, more specifically, the roles these proteins play in digestion and disease; characterizing the function and regulation of intestinal transporters for water and bile acids; and the pathophysiology and treatment of alpha-1-antitrypsin deficiency, the most common genetic disease of the liver in childhood.
Children’s gastroenterologists also head multiple clinical studies. Liver disease is under assault from Children’s pediatric gastroenterologists working to advance potential therapies that range from increasing our understanding of biliary atresia and acute liver failure, liver diseases often treated with liver transplantation, to transplanting hepatocytes as a possible cure for many childhood liver diseases. Clinical studies in pediatric inflammatory bowel disease are also a focus of Children’s gastroenterology researchers. These studies include participation in local and national registries to gather data about outcome and treatment of children with inflammatory bowel disease and an innovative and novel study to define the role of behavioral therapy in treating children with inflammatory bowel disease.
Long-term Safety and Durability of the Therapeutic Effect of LUM001, an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI), in the Treatment of Cholestatic Liver Disease in Pediatric Subjects with Alagille Syndrome
A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1-Antitrypsin Deficiency
Biliary Atresia Study in Infants, Children and Adults
Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)
A Prospective Database of Infants with Cholestasis
Study Comparing the Safety and Efficacy of Prepopik versus Polyethylene Glycol Preparation in Children
Study of a Range of Linaclotide Doses Administered Orally to Children, Ages 7 to 17 Years with Irritable Bowel Syndrome with Constipation
Study of a Range of Linaclotide Doses Administered Orally to Children, Ages 6 to 17 Years, Who Fulfill Modified Rome III Criteria for Child/Adolescent Functional Constipation
Risk Stratification and Identification of Immunogenetic and Microbial Markers of Rapid Disease Progression in Children with Crohn’s Disease
Treating Disrupted Sleep in Individuals with Inflammatory Bowel Disease: A Novel Adjunctive Therapy for Chronic Inflammatory Illness
Autologous Stem Cell Transplantation with CD34 Selected Peripheral Blood Stem Cells (PBSC) in Pediatric and Young Adult Patients with Severe Crohn's Disease
Study of Infliximab in Pediatric Participants with Inflammatory Bowel Disease (ADAPT)
Intestinal Care and Rehabilitation Center Database
Efficacy and Long-term Safety of LUM001, an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTi) in the Treatment of Cholestatic Liver Disease in Pediatric Patients with Progressive Familial Intrahepatic Cholestasis
Longitudinal Study of Mitochondrial Hepatopathies
Molecular Mechanisms of Dietary Fat Digestion by Pancreatic Lipases – Fecal Fat and Duodenal Fluid Collection Research Studies
A Study of Acute Recurrent and Chronic Pancreatitis in Children by the International Study Group of Pediatric Pancreatitis In Search of a Cure (INSPPIRE)
Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis: A Pilot Withdrawal/ Reinstitution Trial
Compassionate Use of Omegaven in the Treatment of Parenteral Nutrition-Associated Hepatic Injury
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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