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Ranked #8 Nationally by U.S. News & World Report.
As a leader in pediatric health care and the world’s premier center for pediatric transplantation, UPMC Children’s Hospital of Pittsburgh’s Hillman Center for Pediatric Transplantation is dedicated to transforming lives through research and scientific study. With research support from government agencies, insurers and the community, UPMC Children’s continues to improve the medical management of pediatric transplant patients and, consequently, increase survival rates for all pediatric transplant patients.
Our research programs and clinical trials are helping to advance pediatric transplantation, with special focus on immunotherapy, transplantation tolerance, organ preservation, bioengineering, living intestine transplants and post-transplant therapies, including the reduction of steroid-based and immunosuppressive drugs.
UPMC Children's is also at the forefront of pediatric heart and lung transplant research. Lab researchers and clinicians work side-by-side to study relevant cardiovascular and transplant-related problems in children. The goal is not only to increase the overall body of knowledge about heart disease and transplantation in children, but also to discover methods to enhance success of the procedures.
In the Pediatric Transplant Research Laboratory, UPMC Children’s investigators are developing ways to improve the effectiveness of anti-rejection medicines so that each child can receive the most appropriate drug at a dose that prevents rejection, but without side effects.
A research team at the Thomas E. Starzl Transplantation Institute is studying specific biological factors that may enable some patients to be successfully weaned from all immunosuppressive therapy. When precise clinical markers can be determined, it may be possible to develop simple tests that could help predict transplant tolerance.
Through groundbreaking research and advanced training programs, Children’s has developed innovative therapies for previously fatal liver and intestinal disorders. Patients of Children’s pediatric intestinal transplant program represent the world’s first and most successful series of small intestine transplants. Children’s also offers pediatric living-related liver transplants as a lifesaving alternative to the national cadaver organ shortage.
Researchers
Clinical Studies
Pharmacodynamics, Pharmacogenomics and Preliminary Safety and Efficacy of Alemtuzumab Induction and Tacrolimus in Pediatric Intestinal Transplantation
Autologous Stem Cell Transplantation with CD34 Selected Peripheral Blood Stem Cells (PBSC) in Pediatric and Young Adult Patients with Severe Crohn's Disease
Psychosocial Functioning and Adherence following Pediatric Intestinal Transplantation
Transmissible Genetic Traits in Transplant Outcomes
Normal Human Subjects for Immune Assay Development
Bilateral Orthotopic Lung Transplant (BOLT) in Tandem With CD3+ and CD19+ Cell Depleted Bone Marrow Transplant (BMT) From Partially HLA-Matched Cadaveric Donors
In Vitro Correlates of Transplant Tolerance in Children Off Immunosuppression
Hepatocyte Transplantation for Acute Decompensated Liver Failure
Hepatocyte Transplantation for Liver-Based Metabolic Disorders
Study of Reduced-Intensity Conditioning In Patients With Non-Malignant Disorders Undergoing Umbilical Cord, Bone Marrow, or Peripheral Blood Stem Cell Transplantation
Pharmacodynamics, Pharmacogenomics and Preliminary Safety and Efficacy of rATG Induction and Tacrolimus Monotherapy in Pediatric Liver Transplantation
Transplant Epstein-Barr Virus (EBV) Disease – Pathogenesis and Immunotherapy
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh One Children’s Hospital Way 4401 Penn Ave. Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.