COVID-19: The Latest Information from UPMC
Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Ranked #8 Nationally by U.S. News & World Report.
PITTSBURGH, Sept. 28, 2016 – Women who experience hot flashes and night sweats earlier in life are more likely to die from cardiovascular disease (CVD) when compared to women with later onset menopausal symptoms, according to research from the University of Pittsburgh School of Medicine published today in the journal, Menopause.
Up to 80 percent of women experience menopausal symptoms, particularly hot flashes and night sweats, at some point during the menopause transition, said Rebecca Thurston, Ph.D., professor of psychiatry, Pitt School of Medicine.
“We used to think these were annoying symptoms that persist for several years around the final menstrual period and simply affect the quality of life for many women,” she said. “However, we now know that these symptoms persist far longer and often start earlier than we previously thought. Our research also suggests that for some women, particularly for younger midlife women, menopausal symptoms might mark adverse changes in the blood vessels during midlife that place them at increased risk for heart disease.”
The research indicates that early onset of menopausal symptoms is associated with dysfunction of the endothelium, which is the lining of blood vessels. Endothelial dysfunction was measured by assessing flow-mediated dilation (FMD), a noninvasive ultrasound measure of how well the vessel dilates in response to pressure on the wall of the blood vessel.
Dr. Thurston and her colleagues investigated associations between menopausal symptoms and risk for CVD complications among postmenopausal women participating in the National Heart, Lung, and Blood Institute Women’s Ischemia Syndrome Evaluation study. A total of 254 postmenopausal women with signs and symptoms of ischemic heart disease were evaluated, and researchers found those who had hot flashes before age 42 to be more likely to have lower FMD, suggesting adverse endothelial changes, as well as higher mortality from heart disease.
“While more work needs to be done to confirm our findings, our research could, one day, help us predict the midlife women who might be at increased risk for cardiovascular disease so that we proactively target these women for early prevention strategies,” Dr. Thurston said.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Support the hospital by making a donation online, joining our Heroes in Healing monthly donor program, or visiting our site to learn about the other ways you can give back.