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For more information about research, please call our main office at 412-692-6438.
Children's Hospital is ranked One of America's Best Children's Hospitals.
Aging is a universal phenomenon that is associated with many functional disabilities as well as susceptibility to age-related diseases such as cancer, neurodegenerative ailments and diabetes. With a rapidly aging global population it is a public health issue of tremendous significance. Research on aging not only helps us understand a fundamental biological phenomenon, but it may also be the least expensive and rapid path to targeting multiple age-associated ailments simultaneously. Recent discoveries have suggested that aging is not just the result of stochastic cellular damage brought on by the travails of living. Instead, it is strongly influenced by genes that appear to be conserved in their longevity functions, from yeast to humans.
Researchers in the Ghazi lab study genes that influence aging to understand the molecular mechanisms that determine longevity in the model organism, Caenorhabditis elegans, a type of worm. C. elegans is particularly suitable for aging research, as it has a short lifespan of about three weeks and displays many anatomical and functional changes that accompany human aging, as seen here in the scanning electron microscopy images of young and old C. elegans taken by our lab.
Our lab is especially interested in the relationship between reproduction and aging, and the genes that govern this complex relationship. Our recent studies have led us to focus on the role of conserved, pro-longevity transcription factors and lipid-metabolic pathways in elucidating the reproductive control of aging. Additional lab interests include the role of proteasomal protein degradation and miRNA pathways in aging.
The Ghazi Laboratory is located at:
John G. Rangos Sr. Research Center
One Children's Hospital Drive
4401 Penn Avenue
Pittsburgh, PA 15224
We welcome inquiries regarding research opportunities in aging. If you have interesting ideas about science and want to investigate available positions, please contact Arjumand Ghazi, PhD, Principal investigator.
To reach the lab by phone please call: 412-692-9258.
For administrative matters, please contact Cindy Vogt, direct dial: 412-692-9448.
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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