The Ghazi Lab - Molecular Genetics of Aging

The Ghazi Lab – Molecular Genetics of Aging

Aging is a universal phenomenon that is associated with many functional disabilities as well as susceptibility to age-related diseases such as cancer, neurodegenerative ailments and diabetes. With a rapidly aging global population it is a public health issue of tremendous significance. Research on aging not only helps us understand a fundamental biological phenomenon, but it may also be the least expensive and rapid path to targeting multiple age-associated ailments simultaneously. Recent discoveries have suggested that aging is not just the result of stochastic cellular damage brought on by the travails of living. Instead, it is strongly influenced by genes that appear to be conserved in their longevity functions, from yeast to humans.

ith a lifespan of only three weeks, C. elegans, helps the Ghazi Lab understand the genetics of aging. Researchers in the Ghazi lab study genes that influence aging to understand the molecular mechanisms that determine longevity in the model organism, Caenorhabditis elegans, a type of worm. C. elegans is particularly suitable for aging research, as it has a short lifespan of about three weeks and displays many anatomical and functional changes that accompany human aging, as seen here in the scanning electron microscopy images of young and old C. elegans taken by our lab.

Our lab is especially interested in the relationship between reproduction and aging, and the genes that govern this complex relationship. Our recent studies have led us to focus on the role of conserved, pro-longevity transcription factors and lipid-metabolic pathways in elucidating the reproductive control of aging. Additional lab interests include the role of proteasomal protein degradation and miRNA pathways in aging.

Contact Us

The Ghazi Laboratory is located at:

John G. Rangos Sr. Research Center
Room 7139
One Children's Hospital Drive
4401 Penn Avenue
Pittsburgh, PA 15224

We welcome inquiries regarding research opportunities in aging. If you have interesting ideas about science and want to investigate available positions, please contact Arjumand Ghazi, PhD, Principal investigator.

To reach the lab by phone please call: 412-692-9258.

For administrative matters, please contact Cindy Vogt, direct dial: 412-692-9448.