Mitochondrial Metabolism Regulation

Regulation of Mitochondrial Metabolism by Reversible Lysine Acylation

A core focus of our laboratory studies is mitochondrial fatty acid oxidation (FAO), the pathway by which fatty acids are broken down for energy. Mutations in the FAO genes are among the most prevalent inborn errors of metabolism. Recently, it was discovered that the FAO enzymes are heavily modified by post-translational modifications, including lysine acetylation and lysine succinylation. There are three mitochondrial sirtuin deacylases (SIRT3, SIRT4, SIRT5), which are believed to reverse some of these modifications. The lab’s current research focuses on the functional effects of lysine acetylation and succinylation on the FAO pathway and the role the sirtuins play in regulating metabolism.

Principal Investigator

Eric S. Goetzman, PhD