Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Download our mobile app today - it's free!
ACAD10 has been implicated in diabetes in humans. ACAD10 knockout mice experiments confirmed a relationship. Although ACAD10 has an ACAD domain very similar to the ACAD family of flavoenzymes, it also has an extra-large domain that we have hypothesized is an electron transfer domain that likely binds nicotinamide adenine dinucleotide (NAD). Moreover, its active site according to the crystal structure of ACAD11 and modeling seem to contain basic residues, implying possibly more than just a α,β-dehydrogenation biochemical function, but perhaps other function comparable to glutaryl-CoA dehydrogenase, which has an additional decarboxylation function. Our latest expression studies in insect cells indicate that a greater than 110 Kd protein and another 48 Kd species could be expressed from the full-length gene cloned in the expression vector. Insect cells expressing the protein(s) will be soon grown in bulk to attempt to purify them and characterize them. Another exciting result from the investigations of ACAD10 in mice is the confirmation of the presence of another ACAD protein, ACAD12. This one is surprisingly very similar to a short peptide at the N-terminus, ~160 amino acids, plus the ACAD domain of ACAD10 to almost 97 percent homology. Our lab is currently pursuing the identification of the function of this version of an ACAD.
Al-Walid A. Mohsen, PhD
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.