Gastroenterology Clinical Studies

Some of the many research opportunities available in Gastroenterology are listed below. Select a study to review a brief description and requirements. Parents or guardians of children who might be eligible are encouraged to inquire about enrollment. Contact information is listed at the end of each study.

Thank you for exploring these opportunities and helping us to find cures and prevent childhood disease.

Clinical Studies

Researchers

Alagille Syndrome and LUM001: The IMAGINE Study – Phase II

Long-term Safety and Durability of the Therapeutic Effect of LUM001, an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI), in the Treatment of Cholestatic Liver Disease in Pediatric Subjects with Alagille Syndrome

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Alpha-1 Antitrypsin Deficiency Study – Phase II

A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1-Antitrypsin Deficiency

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Cholestasis Long-term Observation: The LOGIC Study

Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)

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Colon Cleansing with Prepopik Before Colonoscopy – Phases I & II

Study Comparing the Safety and Efficacy of Prepopik versus Polyethylene Glycol Preparation in Children

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Constipation Treatment with Lubiprostone – Phase III

Study of Lubiprostone in Pediatric Patients with Functional Constipation

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Crohn’s Disease - Risk and Microbial Marker Study

Risk Stratification and Identification of Immunogenetic and Microbial Markers of Rapid Disease Progression in Children with Crohn’s Disease

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Crohn’s Disease and Sleep Disturbance Study – Phase IV

Treating Disrupted Sleep in Individuals with Inflammatory Bowel Disease: A Novel Adjunctive Therapy for Chronic Inflammatory Illness

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Crohn's Disease Treatment using Blood Stem Cells – Phase I/II

Autologous Stem Cell Transplantation with CD34 Selected Peripheral Blood Stem Cells (PBSC) in Pediatric and Young Adult Patients with Severe Crohn's Disease

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ICARE Research Registry

Intestinal Care and Rehabilitation Center Database

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Inflammatory Bowel Disease and Biopsychosocial Effects

Understanding the Biopsychosocial Underpinnings of Abdominal Pain in Inflammatory Bowel Disease

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Mitochondrial Hepatopathies Long-term Observation: The MITOHEP Study

Longitudinal Study of Mitochondrial Hepatopathies

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Pancreatitis INSPPIRE Registry

A Study of Acute Recurrent and Chronic Pancreatitis in Children by the International Study Group of Pediatric Pancreatitis In Search of a Cure (INSPPIRE)

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Pediatric IBD Registry

Understanding the Biopsychosocial Underpinnings of Abdominal Pain in Inflammatory Bowel Disease

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TPN-Related Cholestasis Treatment with Omegaven - Phase II

Compassionate Use of Omegaven in the Treatment of Parenteral Nutrition-Associated Hepatic Injury

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Ulcerative Colitis PROTECT Study – Phase IV

Predicting Response to Standardized Pediatric Colitis Therapy: The PROTECT Study

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Mark E Lowe, MD, PhD

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Feras Tawfiq Alissa, MD

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David J Keljo, MD, PhD

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Robert H. Squires, MD

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Eva M Szigethy, MD, PhD

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