Gastroenterology Clinical Studies

Some of the many research opportunities available in Gastroenterology are listed below. Select a study to review a brief description and requirements. Parents or guardians of children who might be eligible are encouraged to inquire about enrollment. Contact information is listed at the end of each study.

Thank you for exploring these opportunities and helping us to find cures and prevent childhood disease.

Clinical Studies

Researchers

Alagille Syndrome & LUM001: The IMAGINE Study – Phase II

Long-term Safety and Durability of the Therapeutic Effect of LUM001, an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI), in the Treatment of Cholestatic Liver Disease in Pediatric Subjects with Alagille Syndrome

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Alpha-1 Antitrypsin Deficiency Study – Phase II

A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1-Antitrypsin Deficiency

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Biliary Atresia Long-Term Observation: The BASIC Study

Biliary Atresia Study in Infants, Children and Adults

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Bowel Preparation with BLI800 Before Colonoscopy – Phase III

Study of Bowel Cleansing Preparation BLI800 in Pediatric Patients Undergoing Colonoscopy

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Cholestasis Long-term Observation: The LOGIC Study

Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)

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Cholestasis Natural History Database: The PROBE Study

A Prospective Database of Infants with Cholestasis

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Constipation in Patients with IBS Treated with Linaclotide – Phase II

Study of a Range of Linaclotide Doses Administered Orally to Children, Ages 7 to 17 Years with Irritable Bowel Syndrome with Constipation

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Constipation Treatment with Linaclotide – Phase II

Study of a Range of Linaclotide Doses Administered Orally to Children, Ages 6 to 17 Years, Who Fulfill Modified Rome III Criteria for Child/Adolescent Functional Constipation

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Crohn’s Disease - Risk & Microbial Marker Study

Risk Stratification and Identification of Immunogenetic and Microbial Markers of Rapid Disease Progression in Children with Crohn’s Disease

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Crohn’s Disease & its Effect on Growth in Boys & Girls

Sex Differences in Statural Growth Impairment in Pediatric Crohn’s Disease

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Crohn’s Disease & Sleep Disturbance Study – Phase IV

Treating Disrupted Sleep in Individuals with Inflammatory Bowel Disease: A Novel Adjunctive Therapy for Chronic Inflammatory Illness

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Crohn’s Disease Biomarker Study: The GEM Project

Study on the Genetic, Environmental and Microbial Interactions that Cause IBD (GEM Project)

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Crohn's Disease Treatment using Blood Stem Cells – Phase I/II

Autologous Stem Cell Transplantation with CD34 Selected Peripheral Blood Stem Cells (PBSC) in Pediatric and Young Adult Patients with Severe Crohn's Disease

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Hepatitis C Treatment with Glecaprevir & Pibrentasvir – Phase II/III

An Open Label Multicenter Study to Evaluate the Pharmacokinetics, Safety, and Efficacy of Glecaprevir/Pibrentasvir in Pediatric Subjects with Genotypes 1-6 Chronic Hepatitis C Virus Infection

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IBD ImproveCareNow Registry

Using Patient Data to Transform Care and Improve Outcomes for Children, Adolescents and Young Adults with Inflammatory Bowel Disease

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IBD Treatment with Remicade®: The ADAPT Study – Phase IV

Study of Infliximab in Pediatric Participants with Inflammatory Bowel Disease (ADAPT)

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ICARE Research Registry

Intestinal Care and Rehabilitation Center Database

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Intrahepatic Cholestasis & LUM001: The INDIGO Study – Phase II

Efficacy and Long-term Safety of LUM001, an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTi) in the Treatment of Cholestatic Liver Disease in Pediatric Patients with Progressive Familial Intrahepatic Cholestasis

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Mitochondrial Hepatopathies Long-term Observation: The MITOHEP Study

Longitudinal Study of Mitochondrial Hepatopathies

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Pancreatitis INSPPIRE 2 Study

Pediatric Longitudinal Cohort Study of Chronic Pancreatitis (INSPPIRE 2)

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Pancreatitis Pain Management with Web-MAP

A Pilot Study of Web-MAP for Children With Chronic Pancreatitis

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TPN-Related Cholestasis Treatment with Omegaven - Phase II

Compassionate Use of Omegaven in the Treatment of Parenteral Nutrition-Associated Hepatic Injury

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