Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Ranked #8 Nationally by U.S. News & World Report.
The purpose of this multi-center research study is to evaluate the effectiveness and safety of linaclotide for children with functional constipation or chronic constipation that does not have a structural or biochemical explanation. Linaclotide is approved for use in adults for treatment of constipation, but has not previously been studied in children.
Subject to certain exclusion criteria, the study is accepting patients of both genders, ages 6 through 17 years, who have met the modified Rome III criteria for Child/adolescent functional constipation for at least two months.
Boys and Girls: Ages 6 through 17 years
Following a 4-week screening period and 2- to 3-week pretreatment period, participants will be randomly assigned to receive either the linaclotide study drug or a placebo to take by mouth once a day for 4 weeks. Participants age 6 to 11 will take a liquid solution, and older participants will take either a capsule or liquid solution. During study visits, patients will receive physicals, testing, and instructions on lifestyle modifications to help treat constipation.
Duration: About 12 weeks
Forest Research Institute
Study Description at National Institutes of Health
Constipation, Age 11 and Younger
Constipation, Age 12 and Older
Arvind I. Srinath, MD
For more information about the study or enrollment, please contact:
Amy Bookser, RN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.