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The purpose of this study is to see if vaccination with a “cocktail” of glioma epitope peptide, combined with the immunoadjuvant polyICLC, can induce immune responses in children with newly diagnosed or recurrent gliomas. Eligible patients are stratified by tumor and prior treatment:
Subject to certain exclusion criteria, the trial is enrolling participants of both genders, ages 18 months to 21 years, who satisfy study criteria, including having either a newly diagnosed, incompletely resected, non-brain stem high-grade glioma; a newly diagnosed diffuse intrinsic pontine glioma or any biopsy-proven high-grade glioma; or a recurrent low- or high-grade glioma. Patients must have the HLA-A2 tissue type.
Males: Ages 18 months to 21 years
Females: Ages 18 months to 21 years
A vaccine made from small proteins specific to gliomas will be given in combination with an experimental drug called Poly-ICLC, which boosts the immune system. Both will be given by subcutaneous injections at 3-week intervals for the first 24 weeks. Responding patients may continue receiving vaccines every 6 weeks for up to 2 years. Physical examinations, blood testing, and MRI scans will be performed periodically.
Frequency of visits: Every 3 weeks for 8 times, then every 6 weeks up to 2 years
Duration: Up to 2 years for treatment
The Brain Tumor Society
National Institutes of Health
Study Description at National Institutes of Health
Ian F. Pollack, MD
Hideho Okada, MD, PhD
For more information about the study or enrollment, please contact:
Sharon DiBridge, CRA
Angela Connelly, Research RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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