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This multicenter trial by the Children’s Oncology Group seeks to determine the best dose of BMN 673 and temozolomide and to see how well they work in treating younger patients with tumors that have come back or have not responded to standard therapy. BMN 673 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Researchers believe that giving BMN-673 together with temozolomide may work better in younger patients with refractory or recurrent malignancies.
Subject to certain exclusion criteria, this study is open to patients of both genders ages 13 months to 21 years for Phase I of the study, or up to 30 years of age for Phase II, who have been diagnosed as having recurrent or refractory malignancies, including solid tumors, Ewing sarcoma and acute lymphoblastic leukemia.
Males and Females: Ages 13 months to 30 years
Patients enrolled in the study will take BMN 673 orally on the first day of treatment, and in combination with temozolomide on days 2 through 5. This pattern will be repeated in 28-day cycles for up to 24 cycles.
Visits: About 15 clinic visits during the first cycle, and thereafter about once a week
Duration: About 2 years, depending on outcomes
Children’s Oncology Group (ADVL1411)
National Cancer Institute, Cancer Therapy Evaluation Program
Study Description at National Institutes of Health
Jean Tersak, MD
For more information about the study or enrollment, please contact:
Research Coordinator Angela Connelly, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.