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This multicenter trial by the Children’s Oncology Group seeks to determine the best dose of nivolumab when given with or without ipilimumab, to see how well it works in treating younger patients with solid tumors or sarcomas that have come back or have not responded to standard therapy. Monoclonal antibodies, such as nivolumab and ipilimumab, may block tumor growth in different ways by targeting certain cells.
Subject to certain exclusion criteria, study Parts A, B7, and C of this study are open to patients of both genders, ages 13 months to 18 years, with recurrent or refractory solid tumors or metastatic, relapsed, or refractory melanoma; and study Parts B1-B6 are designed for patients 13 months to 30 years of age with relapsed or refractory neuroblastoma, osterosarcoma, rhabdomyosarcoma, Ewing sarcoma, peripheral primitive neuroectodermal tumor, or lymphoma.
Males and Females: Ages 13 months to 30 years
Patients enrolled in the study will receive the study drugs by intravenous infusion at intervals specified by the protocol, which varies based on type of tumor.
Visits: Variable, determined by study part in which patient is enrolled
Duration: Patients will be followed for up to 5 years after completing protocol therapy.
Children’s Oncology Group (ADVL1412)
National Cancer Institute
Study Description at National Institutes of Health
Jean Tersak, MD
For more information about the study or enrollment, please contact:
Research Coordinator Angela Connelly, RN, BSN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
UPMC Children’s Hospital of Pittsburgh
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.