Asthma Cohort Study

Longitudinal Cohort Study to Determine How Air Pollutants Affect the Health of Children with Asthma

Protocol Description

This comprehensive long-term study is being done to determine how environmental air pollutants and other factors affect the health of children with asthma and to understand the role these exposures have in mediating asthma outcome disparities often seen among children residing in inner cities. With a focus on Western Pennsylvania’s Mon Valley region, the study will examine the role of ambient pollutants, nutrition, psychosocial factors and gene-environment interactions on chronic respiratory problems.

Eligibility Criteria

The study will enroll children of both genders, ages 6 to 13, living within the study region, who have been previously diagnosed as having asthma or who are considered at risk for asthma with a diagnosis subsequently confirmed by Pediatric Environmental Medicine Center researchers. The study region encompasses the Woodland Hills, South Allegheny and Clairton City school districts.
Boys: Ages 6 to 13
Girls: Ages 6 to 13


The screening process consists of two visits for lung testing. Enrolled participants will then have a baseline visit with follow-up visits scheduled approximately 6 months apart for a total of 5 years. During visits, participants and their parents/guardians will complete various questionnaires, such as quality of life and smoking exposure questionnaires. Additionally, limited physical examinations will be given as well as follow-up respiratory tests, and blood, saliva and urine sampling. All visits will occur at the Pediatric Clinical and Translational Research Center of Children’s Hospital of Pittsburgh of UPMC.
Visits: 13
Duration: 5 years

Status: Open for Enrollment

Source(s) of Support

The Heinz Endowments

Primary Investigator

Fernando Holguin, MD, MHP

Contact Information

Tracey Dill, RRT