Children's Hospital is part of the UPMC family.
Be safe anytime, anywhere.
To find a pediatrician or pediatric specialist, please call 412-692-7337 or search our directory.
A resource for our network of referring physicians.
For more information about research, please call our main office at 412-692-6438.
Children's Hospital is ranked One of America's Best Children's Hospitals.
The purpose of this multicenter study is to examine the DNA of children with congenital diaphragmatic hernia (CDH) and their parents to determine whether certain genes influence the likelihood of CDH. CDH is a birth defect in which the baby’s diaphragm fails to close completely during development, leaving an opening between the abdominal cavity and the chest cavity that allows abdominal organs to push up into the chest. The study also seeks to identify syndromes associated with newly discovered genetic changes in patients with CDH. This knowledge may ultimately lead to advances in the diagnosis, prognosis, prevention and treatment of patients born with this condition.
Newborns of both genders, who have been diagnosed with CDH and their biological parents are eligible.
Blood samples from both the child and parents will be collected for analysis. Additionally, 2 tiny tissue samples will be collected for genetic analysis at the time of the child’s corrective surgery. Clinical data about the child’s diagnosis will also be collected. Participants will undergo follow-up procedures scheduled as part of their standard care for CDH: echocardiogram at 1 and 3 months of age, developmental assessment at 2 years of age and a digital facial photograph to correlate genetic findings with clinical features.
Visits: None beyond standard care for CDH
Duration: 2 years
National Institute of Child Health and Development
DHREAMS Study Website
Study description at National Institutes of Health
Douglas Potoka, MD
Laurie Luther, BSN, RN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
With myCHP, you can request appointments, review test results, and more.
For questions about a hospital bill call:
To pay your bill online, please visit UPMC's online bill payment system.
Interested in giving to Children's Hospital? Visit Children's Hospital of Pittsburgh Foundation's website to make a donation online.