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The purpose of this study is to see if giving vitamin D to patients with cystic fibrosis can reduce allergic reactions to the common fungus Aspergillus fumigatus found in throat cultures. This allergic reaction, also called ABPA, causes some patients to wheeze, cough or have difficulty breathing. Conventional treatment with “anti-fungal” medicine and high-dose steroids may be problematic for some, due to side effects on blood sugar levels and the bones. Recent studies have suggested that vitamin D is a critical factor in the development of cells that suppress allergic reactions.
Subject to certain exclusions, this study is open to patients of both genders, ages 12 and up, with a confirmed diagnosis of cystic fibrosis and past or present respiratory culture positive for Aspergillus fumigatus.
Males: Age 12 and older
Females: Age 12 and older
Following the initial screening visit, participants will be given a supply of cholecalciferol (vitamin D3) to be taken orally every day for six months, in addition to the patient’s routine vitamin D supplement. At check up visits, examinations will include blood and urine sampling, and pulmonary function tests.
Duration: 26 weeks
National Heart, Lung and Blood Institute
Study Description at National Institutes of Health
Joseph M. Pilewski, MD
For information, please contact:
Elizabeth Hartigan, MPH, RN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
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