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Through this study, researchers will compare the effects of an inhaled concentrated sodium chloride (salt) solution versus an inhaled solution of sodium bicarbonate in decreasing the thickness and stickiness of mucus that forms in the airways of people with cystic fibrosis. The thick sticky mucus can be difficult to clear by coughing and forms an environment for bacterial infections to develop. Researchers believe sodium bicarbonate may also be helpful in decreasing the typically higher acidity of airways in people with cystic fibrosis.
Children of both genders who have cystic fibrosis and have been clinically stable in the month prior to enrollment and are able to clear mucus well.
Males and Females: Ages 12 and older
The study requires 2 visits to either Children’s Pediatric Clinical and Translational Research Center or the Clinical Translational Research Center of Monifiore Hospital. Each visit will take approximately 13 hours to complete. During visits, participants will be examined, given various pulmonary tests and will be monitored throughout the study day. A study medication will be provided by nebulizer early in the visit and again four hours later.
Duration: 15 days
Cystic Fibrosis Foundation
National Institutes of Health
Joseph M. Pilewski, MD
For information or to enroll, please contact:
Elizabeth Hartigan, MPH, RN
Children's Hospital's main campus is located in the Lawrenceville neighborhood. Our main hospital address is:
Children’s Hospital of Pittsburgh of UPMC
One Children’s Hospital Way
4401 Penn Ave.
Pittsburgh, PA 15224
In addition to the main hospital, Children's has many convenient locations in other neighborhoods throughout the greater Pittsburgh region.
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